Project Grant R44EY034064
- The National Eye Institute (NEI) awarded a $256,296 Project Grant (CFDA 93.867 - Vision Research) to The General Hospital Corporation (Massachusetts General Hospital) to develop new "Auto-Sensing, Instantaneous Adaptive Ranging Optical Coherence Tomography (OCTA)" technology. This technology aims to expand the imaging depth range of OCTA systems, enabling improved visualization of the critical peripheral retinal microvasculature. The project will leverage advances in integrated...
- This $617,201 Project Grant awarded by the National Eye Institute's Vision Research program aims to leverage innovative tools from engineering, AI, and advanced optical coherence tomography (OCT) imaging to directly observe and unveil the specific mechanical insults to retinal ganglion cell axons that contribute to vision loss progression in glaucoma patients. The research team from Emory University intends to monitor glaucoma patients longitudinally to identify where these axonal insults,...
- This federal Project Grant award of $315,825.00 from the National Eye Institute (CFDA 93.867 Vision Research) supports the development of a new, non-invasive, remote photonic technology for intraocular pressure (IOP) biomonitoring in glaucoma patients. The technology, called Photonic IOP Biomonitoring (PIB), uses sound waves and laser speckle pattern monitoring to deduce IOP without the need for physical eye contact or clinician interpretation. The goal is to miniaturize PIB into monoculars or...
- This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), is providing $306,462 to Ifocus Imaging LLC to develop a software platform called OCT-ART-DR. The platform will automate the diagnosis and staging of diabetic retinopathy using optical coherence tomography angiography (OCTA) imaging and artificial intelligence. The key products to be delivered under this award include: 1) Improved AI-based segmentation of OCTA image...
- The Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports the development of an accurate, non-invasive, and automated 24-hour intraocular pressure (IOP) monitoring device. The overarching goal is to create a wearable IOP monitor that can improve the clinical management of glaucoma, the leading cause of irreversible blindness. The $713,964 award will fund research activities over a 5-year period from March 2025 to February 2030 at the University of California,...
- The National Eye Institute (NEI) awarded Kineolabs, Inc. a $300,001 Project Grant under the Vision Research program (CFDA 93.867) to develop a portable, low-cost line-scan swept-source optical coherence tomography (LS-SS-OCT) imaging system. The objective is to use this LS-SS-OCT technology for early detection and monitoring of age-related macular degeneration (AMD), diabetic retinopathy, and other eye diseases. The project aims to make OCT imaging more affordable and accessible to reduce the...
- The National Eye Institute awarded a $245,243 Project Grant to Duke University to develop and validate a novel method for measuring ocular pulse amplitude (OPA) in normotensive and hypertensive eyes. The grant, funded under the Vision Research federal grant program (CFDA 93.867), aims to improve the measurement of intraocular pressure (IOP), which is critical for detecting and managing glaucoma. The project has two specific objectives: 1) validate applanation-based OPA measurements on...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) aims to develop and validate a novel Adaptive Optics Optical Coherence Tomography (AO-OCT) system tailored for high-resolution, wide-field retinal imaging in small animal models, specifically mice. The $305,000 project, awarded on September 1, 2025, with an expected completion date of August 31, 2026, has two key objectives: Develop and optimize a portable AO-OCT system with enhanced imaging capabilities...
- This $417,162 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research on using optical techniques to detect early signs of glaucoma, the leading cause of irreversible blindness worldwide. The University of Houston System, the grantee, will conduct research to determine if changes in the birefringence (optical properties) of the lamina cribrosa and posterior eye structures can serve as sensitive early indicators of glaucoma before structural damage...
- This $745,607 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports the development of the RETIVUE ENTIREEYE, a handheld, high-resolution, non-contact, single-image, widefield retinal screening camera for premature and healthy newborn babies. The device utilizes a novel all-digital, no moving parts scanning light module to capture a seamless, high-quality, diagnostic ultra-widefield image of the entire baby eye in a single shot. This technology has the...
OCULAR BLOOD FLOW IMAGING FOR GLAUCOMA ASSESSMENT - ABSTRACT GLAUCOMA IS ONE OF THE LEADING CAUSES OF BLINDNESS IN ADULTS WORLDWIDE. THERE IS NO SINGLE INSTRUMENT THAT CAN DIAGNOSE GLAUCOMA IN ALL CASES REQUIRING A COMBINATION OF METHODS INCLUDING STANDARD AUTOMATED PERIMETRY TO ASSESS PERIPHERAL VISION, OPTICAL COHERENCE TOMOGRAPHY (OCT) TO ASSESS RETINAL NERVE FIBER LAYER (RNFL) THINNING, INTRAOCULAR PRESSURE (IOP), AND FUNDUS PHOTOGRAPHY TO ASSESS THE CUP TO DISC RATIO. RNFL CHANGES ARE CHALLENGING TO ASSESS IN INDIVIDUALS WITH A HIGH DEGREE OF MYOPIA AS WELL AS IN PATIENTS THAT HAVE PREVIOUSLY BEEN TREATED WITH LASER IN THE EYE. OCULAR BLOOD FLOW (OBF) INFORMATION FROM POSTERIOR SEGMENT, AS OBTAINED BY AN FDA-CLEARED INSTRUMENT CALLED XYCAM RI DEVELOPED BY US, HAS THE POTENTIAL TO ADD INSIGHTS RELEVANT TO GLAUCOMA STATUS THAT ARE COMPLEMENTARY TO CONVENTIONAL METHODS. OUR PRELIMINARY RESULTS HAVE DEMONSTRATED SIGNIFICANT DIFFERENCES IN OBF PATTERNS IN THE OPTIC DISC AND MACULAR REGIONS IN GLAUCOMA SUBJECTS AND HEALTHY CONTROLS. OUR PRESENT PHASE II PROJECT SEEKS TO VALIDATE THE DIAGNOSTIC POTENTIAL OF OBF METRICS OBTAINED BY XYCAM RI IN THE MANAGEMENT OF GLAUCOMA THROUGH A RIGOROUS CLINICAL STUDY WITH AGE-MATCHED, RACE-MATCHED, AND SEX-MATCHED CONTROLS, AND SPECIFICALLY DEMONSTRATE THE USEFULNESS OF OBF-DERIVED MEASUREMENTS IN ASSESSMENT OF GLAUCOMA IN HIGHLY MYOPIC PATIENTS. WE ALSO SEEK TO DEVELOP AND BRING TO MARKET AN ENHANCED MULTI-FUNCTION FUNDUS CAMERA CALLED THE XYCAM FC FOR CLINICAL USE. THE XYCAM FC WILL PERMIT PRACTITIONERS TO VISUALIZE FUNDUS PHOTOS IN STEREO MODE TO ASSESS CUP-TO-DISC RATIO AND ALSO OBF INFORMATION INCLUDING THE MOST DIAGNOSTICALLY RELEVANT FEATURES. AS A FRONTIER TECHNOLOGY THAT COMPLEMENTS COLOR FUNDUS IMAGES WITH VIDEO DATA ON OBF DYNAMICS AT A HIGH TEMPORAL RESOLUTION, THE XYCAM FC OFFERS THE ABILITY TO PERFORM REIMBURSABLE PROCEDURES OF FUNDUS PHOTOGRAPHY, ENABLE AN OPHTHALMOLOGIST OR OPTOMETRIST TO VISUALIZE GLAUCOMA PATHOPHYSIOLOGY, AND CONDUCT RESEARCH ON DEVELOPMENT OF OBF-BASED BIOMARKERS FOR OPHTHALMIC AND SYSTEMIC PATHOLOGY WITH SYMPTOMS IN THE OCULAR VASCULATURE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/15/25 | ||
| Not listed | $245.8k | 9/18/23 | ||
| Not listed | $875.0k | 5/30/23 | ||
| Not listed | $875.0k | 5/30/23 | ||
| Not listed | $674.9k | 5/3/22 |