Project Grant R44DA056316
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...
- This $586,936 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of a low-cost, disposable urine test strip that can rapidly and quantitatively measure substance use disorder (SUD) medication drugs and their metabolites. The award recipient, Vitan-Biotech LLC, will create a point-of-use lateral flow assay (LFA) test strip that leverages innovative signal amplification technology to...
- This $306,872 project grant, awarded on February 1, 2025 by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports the validation of a novel bioassay platform developed by Xcellassay, Inc. to identify individuals, particularly youth athletes, using anabolic androgenic steroids (AAS). The technology leverages a high-throughput androgen receptor (AR) bioassay to quantify androgen levels in blood samples collected on filter paper,...
- This federal Project Grant award of $489,500.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to evaluate the use of remote oral fluid testing to assess cannabis non-use in clinical trials involving younger adults aged 18-30 years. The key products or services to be delivered through this 2-year project, which runs from June 1, 2025 to May 31, 2027, include: Evaluating the completion and performance of daily oral fluid...
- The National Science Foundation (NSF) Division of Electrical, Communications and Cyber Systems awarded a $399,541 Project Grant to the Trustees of Dartmouth College to develop a high-throughput, label-free, and portable sensor that can quantitatively detect multiple illicit drugs including opioids, cocaine, psychostimulants, and methadone in liquid samples such as biofluids. The project aims to create a silver or gold nanoparticle-decorated zinc oxide nanorod coated silica nanofiber matrix...
- This $250,000 Project Grant award, provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), will enable Montana State University Billings (MSUB) to acquire an Agilent 1290 Infinity Series II Ultra-High-Performance Liquid Chromatography (UHPLC) system integrated with an Agilent 6530 Quadrupole Time-of-Flight (QTOF) mass spectrometer. This cutting-edge analytical instrumentation will support advanced biomedical research and education at MSUB,...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Abuse and Addiction Research Programs (CFDA 93.279) provides $318,257 to Cari Health, Inc. to develop a therapeutic monitoring system (TMS) for remote medication compliance tracking of methadone treatment for opioid use disorder (OUD). The key products and services to be delivered include: 1) Integrating an electrochemical sensor, microneedle array, and data pipeline into a prototype wearable...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting the development of a software-based medical device (SAMD) for detecting opioid use through voice analysis. The $800,000 award to Tenvos Inc., a minority-owned and woman-owned technology company, aims to advance the company's AI-driven solution that can enable patients to remotely test for opioid use and securely share results with...
- This $512,256 Project Grant from the National Institutes of Health's National Institute on Drug Abuse will support Health Outcomes Inc. doing business as Telesage to develop a Primary Care-SUD Intake System (P-SUD-IS). The P-SUD-IS aims to address underdiagnosis of substance use disorders (SUDs) by streamlining the SUD assessment process for primary care clinicians. Telesage will create a HIPAA-compliant, automated, cloud-based system to facilitate completion of biopsychosocial assessments for...
- The National Institute of Justice (NIJ) awarded a $319,172 Project Grant under the NIJ Research, Evaluation, and Development Project Grants program (CFDA 16.560) to Research Triangle Institute (RTI International), an independent non-profit research organization. The grant funding will support evaluating the use of direct mass spectrometry technology, specifically the Luxon ion source, to improve the efficiency and capabilities of toxicology laboratories in screening for drugs related to...
COMPACT LIQUID CHROMATOGRAPHY FOR ROUTINE SCREENING IN DRUG TREATMENT CENTERS - PROJECT SUMMARY THE SUBSTANCE ABUSE AND MENTAL HEALTH SERVICES ADMINISTRATION (SAMHSA) HAS SET GUIDELINES FOR ILLICIT DRUG MONITORING FOR BOTH SCREENING AND CONFIRMATORY TESTS. POINT-OF-CARE (POC) SCREENING ASSAYS USUALLY RELY UPON IMMUNOASSAYS THAT LACK SPECIFICITY AMONG COMPOUNDS IN A GIVEN DRUG CLASS. CONFIRMATION TESTING USUALLY EMPLOYS CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY (MS), WHICH IS A POWERFUL TECHNIQUE CAPABLE OF IDENTIFYING THE RELEVANT ANALYTES OF INTEREST IN COMPLEX SAMPLES; HOWEVER, THIS APPROACH REQUIRES LARGE, EXPENSIVE EQUIPMENT THAT REQUIRES TECHNICAL EXPERTISE TO OPERATE, THUS PRECLUDING IT FROM POC ENVIRONMENTS. IN THIS FAST-TRACK SBIR PROJECT, SCIENTISTS AT AXCEND CORPORATION IN COLLABORATION WITH CHROMATOGRAPHY AND DRUG ANALYSIS EXPERTS IN ACADEMIA AND ADVICE FROM PRACTICING HEALTH CARE PROFESSIONALS WILL PURSUE FURTHER DEVELOPMENT OF A COMPACT CAPILLARY LIQUID CHROMATOGRAPHY (LC) PLATFORM FOR RAPID POC SCREENING OF DRUGS OF ABUSE. IN PHASE I, SAMPLE PREPARATION WITH A NOVEL SOLID PHASE EXTRACTION (SPE) APPARATUS WILL BE OPTIMIZED AND AUTOMATED, A LONGER PATHLENGTH UV ABSORPTION DETECTOR FLOW CELL WILL BE CREATED, AND CAPILLARY LC STATIONARY PHASES AND MOBILE PHASES WILL BE INVESTIGATED AND SELECTED TO ACHIEVE SAMHSA TESTING CONCENTRATION CUTOFF LIMITS FOR RELEVANT COMPOUNDS USING THE COMPACT LC SYSTEM. IN PHASE II, NOVEL COLUMN-COLUMN AND COLUMN- DETECTOR COMBINATIONS, DIODE-ARRAY DETECTION MODULES, AND DATA PROCESSING APPROACHES COMBINING CHROMATOGRAPHIC RETENTION TIMES AND UV ABSORPTION RATIOS WILL BE DEVELOPED TO ENHANCE THE ANALYSIS OF THESE COMPOUNDS AND PROVIDE TIMELY INFORMATION TO SUPPORT URGENT PATIENT TREATMENT DECISIONS. KEY ASPECTS OF THIS PROPOSAL THAT ARE UNIQUE TO ADVANCING THE FIELD OF POC CHEMICAL ANALYSIS USING CAPILLARY LC ARE (1) IMPROVED SENSITIVITY USING NOVEL SIMPLE OFF-LINE AND ON-LINE EXTRACTION AND CONCENTRATION DEVICES, AND A LONGER PATHLENGTH UV-ABSORPTION FLOW CELL; (2) COMBINATIONS OF COLUMNS, SOLVENTS, AND MODES OF OPERATION FOR MAXIMUM LC SEPARATION, AND (3) ENHANCED SELECTIVITY OF DETECTION USING INNOVATIVE TANDEM COLUMN-UV-DETECTOR COMBINATIONS, (4) A NEW COMPACT DAD UV-ABSORPTION DETECTOR FOR CAPILLARY LC, AND (5) UNIQUE DATA HANDLING SOFTWARE ALGORITHMS FOR PEAK DECONVOLUTION. THESE INNOVATIONS ARE NEW TO THE AREA OF POC ANALYSIS AS WELL AS TO THE BROAD FIELD OF CAPILLARY LC IN GENERAL. THE RESULTS FROM THIS PROJECT WILL BE A CRITICAL STEP TOWARDS THE RELEASE OF A POC DRUG SCREENING SOLUTION THAT PROVIDES IMPROVED PATIENT CARE COMPARED TO CURRENT HEALTHCARE PRACTICES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($540k) | 5/2/25 | ||
| Not listed | $540.2k | 5/2/25 | ||
| Not listed | $0 | 4/17/25 | ||
| Not listed | $0 | 4/17/25 | ||
| Not listed | $803.6k | 4/17/25 |