Project Grant R43TR005720
- The National Center for Advancing Translational Sciences (NCATS) awarded a $1,050,276 Project Grant to Syntr Health Technologies, Inc. on September 25, 2025 under the CFDA 93.350 Federal Grant Program. This funding supports the development and automation of an FDA-cleared CD-microfluidic platform for rapid tissue microsizing. The platform technology can process a variety of tissue types, including cancer tumors and adipose tissue, to enable single-cell analysis and regenerative medical...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $356,500.00 to Syntr Health Technologies, Inc. to accelerate the development of their SYNTRFUGE and SYNTRFPU360 tissue processing platform technology. This platform aims to enable large-volume tissue processing, including for tumor tissue analysis and adipose tissue for breast cancer reconstructive surgery and other regenerative medicine applications. The funds will support...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...
- This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, provides $329,272 to Capienda Biotech, LLC to develop a high-throughput kinetic system for small-molecule drug discovery. The goal is to create an innovative instrument that can rapidly characterize the binding kinetics of compounds targeting human cyclin-dependent kinases, which are important oncology targets. This will help medicinal chemists identify drug candidates...
- This $306,872 Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) supports the development of a 3D printed integrated sample preparation and chromatography platform for proteomics research at Millennial Materials & Devices Inc., a small disadvantaged business located in Stony Brook, New York. The project aims to fabricate customized 3D printed carbon microbead stationary phase materials and additive manufacturing tools to create an integrated...
- This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
- This $295,924 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to develop and demonstrate a high-yield microfluidic device for the enrichment and capture of CD3+ T cells. This device is intended to improve the manufacturing of autologous and allogenic engineered cell therapies such as CAR-T, which currently have time-consuming and costly production processes. The key objectives are to (1)...
- This $600,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program aims to develop an innovative Optomagnetic Twisting Cytometry (OMTC) system to quantify the dynamic viscoelastic properties of 3D tissue samples. The project will construct an optical scanning system to enable simultaneous measurements of hundreds of thousands of microparticles within a large field-of-view, advancing the understanding of the mechanical properties of live...
- The National Center for Advancing Translational Sciences (NCATS), through its CFDA 93.350 Federal Grant Program, awarded a $294,541 Project Grant to Cellular Vehicles Inc. on June 1, 2024. The purpose of this award is to develop an automated system for producing and delivering cell-laden hydrogel therapies. The project aims to create a novel, standardized process for formulating, encapsulating, and directly injecting cell-laden hydrogels into diseased tissues. This is intended to improve the...
- This $339,300 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports Triangle Biotechnology's development of a nanodroplet-enhanced sonication technology called ChromExtract. The goal is to enable high-quality, high-yield, and consistent chromatin extraction from formalin-fixed, paraffin-embedded (FFPE) tissue samples for downstream chromatin profiling and accessibility analyses. The...
This federal Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350 provides $406,500.00 to Syntr Health Technologies, Inc. to develop an automated, microfluidic tissue dissociation platform called the SYNTRFUGE. This device aims to rapidly and efficiently process solid tumor tissue samples into single cells for diagnostic analysis and research, addressing a critical barrier to more widespread use of single-cell analysis in oncology. The technology combines a proprietary microfluidic tissue dissociation device with centrifugal microfluidic (CD-LOC) capabilities to increase processing speed and reduce clogging, enabling faster and more representative single-cell isolation from tumor samples. This project builds on Syntr Health's previous work in this area and is expected to be completed by August 2026, advancing translational science by improving tools for understanding tumor heterogeneity and developing targeted cancer therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $406.5k | 8/2/25 |