This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, provides $275,000 to Nectagen Inc. to develop custom nanoclamp affinity chromatography resins for the efficient purification of plasma proteins. The goal is to create a bioprocess-compatible affinity chromatography platform that can achieve high-purity recovery of plasma-derived therapeutics, which is critical given the rising demand and high costs of these treatments. The specific aims are to identify and select lead nanoclamp ligands for 5 relevant plasma-based therapeutics, and then optimize the linker lengths and resin composition to maximize recovery and purity of the target proteins from plasma. Successful completion of this project will yield a versatile platform for developing affinity chromatography resins to enable improved downstream processing and purification of complex biological samples, with potential applications in the biopharmaceutical industry.
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