Project Grant R43TR004888

Award Date 1/1/24
Completion Date 12/31/24
Dollars Obligated $290K
Federal Grant Program
93.350
Assistance Type
Project Grant
Place of Performance
Washington, USA
Similar Awards
This $228,697 National Science Foundation award under the Engineering program (CFDA 47.041) will support the development of an optical biosensor technology to facilitate drug screening and validation efforts. Auctus Biologics, Inc. will utilize a proprietary temperature, pH, and chemically stable protein composed of two fragments that bind with antibody-like affinity and specificity. Over the one-year period ending January 2023, the company will establish the technology's suitability for...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $257,807 Project Grant (CFDA 93.286) to the University of California, San Diego (UCSD) to develop a living biosensor technology for rapid, low-cost DNA diagnostics. The proposed project aims to create a hybrid living biosensor/lateral flow assay that can detect and analyze DNA sequences in raw samples without extensive purification. The biosensors will leverage bacterial competence and CRISPR-Cas systems to...
This $242,687 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a next-generation nanopore biosensor technology for the ultrasensitive detection and quantification of multiple infectious disease biomarkers at the point-of-care. The key objectives are to: (1) optimize a highly sensitive, robust, and reproducible nanopore biosensor; (2) enable specific biomarker detection through automated immunoprecipitation and novel signal...
This $1,200,000 federal Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) aims to develop innovative sensing technologies that will enable more frequent and comprehensive blood and urine testing to improve early disease detection. The University of California, Berkeley is the prime awardee and plans to integrate biosensors enabled by DNA nanotechnology with complementary metal-oxide-semiconductor...
This $1,165,298 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop novel nanopore- and click-chemistry-based approaches for rapid, culture-independent detection of sepsis-causing pathogens directly from blood samples within 2 hours. The project will engineer nanopore biosensors and multiplex click chemistry-amplified nanopore sensing to target proteomic biomarkers like outer...
This $448,818 Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) aims to develop a miniaturized, sensitive, and user-friendly electromagnetic (EM) sensing platform for rapid bacterial diagnostics. The project leverages integrated circuit (IC) chips and microfluidic integration to create a portable system capable of distinguishing bacterial phenotypes and detecting strain-specific surface biomarkers. Key innovations include: 1)...
This $980,779 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program aims to develop an adaptable and deployable plasmonic sensing platform for infectious disease surveillance. The key products and services to be delivered include: Designing catalytic surface-enhanced Raman scattering (SERS) sensors based on functional DNA...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Giant Biosystems Inc. aims to develop a rapid point-of-care antimicrobial susceptibility testing (AST) kit. The proposed microfluidic platform can generate actionable results within 6-9 hours, significantly faster than current methods which require 3-5 days. This will allow physicians to prescribe the most effective antibiotic at the optimal dosage sooner, reducing...
This $380,074 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The goal is to create a device that can report the presence and quantity of specific biomarkers through a simple yes/no readout based on bubble formation, enabling accessible molecular diagnostics for a wider range of diseases and situations. The project will...
This Project Grant award for $300,000.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop rapid, point-of-care diagnostic tests for the early detection of leptospirosis, a potentially fatal zoonotic bacterial disease. The key objectives are to: Optimize and validate solid phase antigen-detection tests using leptospiral virulence-modifying proteins (VMP), lipoprotein LipL32, and...

The federal Project Grant award from the National Center for Advancing Translational Sciences (NCATS), part of the 93.350 CFDA program, will support the development of a novel biosensor for the detection of bacterial endotoxins. Through this $290,066 award, the awardee Monod Bio, Inc. will focus on (I) computational design and experimental selection of functional lipopolysaccharide (LPS) bioluminescent biosensors, (II) in vitro evolution of these biosensors to optimize sensitivity and stability, and (III) optimization of the LPS detection assay conditions and formulation of a 96-well kit. The project aims to develop alternative protein-based endotoxin biosensors that provide advantages over current techniques, including improved sensitivity, broader dynamic range, and greater stability and cost-effectiveness. Successful development of these LUCCAGE biosensors could enable the biotechnology industry to access sustainable, inexpensive, and robust endotoxin bioassays.

Generated 8/13/24, 6:49 AM