This $650,000 Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, supports research and development for a next generation probiotics-based platform technology to enable oral delivery of peptide and protein therapeutics. Specifically, the project aims to (1) develop an antibiotic-resistance-free expression system for stable, high-level production of therapeutic peptides in Lactobacillus probiotic strains, (2) create inducible kill-switch mechanisms for biocontainment of the engineered probiotics, and (3) validate the efficacy and stability of the engineered probiotic delivery system in animal models. If successful, this novel platform could enable oral administration of peptide and protein drugs for treating a broad spectrum of chronic diseases, while providing advanced biocontainment capabilities. The award to Medosome Biotec LLC, a for-profit R&D services company, runs from August 1, 2023 through July 31, 2024.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 8/15/23 | ||
| Not listed | $325.0k | 7/27/23 | ||
| Not listed | $325.0k | 7/27/23 |