Project Grant R43HG014985
- The National Center for Advancing Translational Sciences at the National Institutes of Health, under the Department of Health and Human Services, awarded $957,707 to Cytoterra Inc. on July 1, 2026, through the NCATS Program (CFDA 93.350). Cytoterra will develop and validate a high-throughput genomic integrity assessment platform for allogeneic cell therapies. The project combines genomic proximity mapping technology with whole exome sequencing in a platform called Cytoterra Plus to detect...
- The National Institute of General Medical Sciences awarded the Pacific Northwest Research Institute $1,231,446 in project grant funding on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the origin and functional impact of "hidden" structural variants in rare genetic diseases. The research examines DNA structural variants including inversions, complex genomic rearrangements, mobile element insertions, and balanced...
- The National Institutes of Health National Human Genome Research Institute awarded New York Genome Center, Inc., $2,677,663 on June 22, 2026, under the Human Genome Research program (CFDA 93.172, Assistance Listing designation R01HG014032) to develop next-generation spatial multi-omics technologies. The recipient will design a cost-effective, user-friendly platform for spatial multi-omic profiling that integrates chromatin states, transcriptional activity, and other modalities simultaneously...
- The National Institutes of Health National Human Genome Research Institute awarded New York University $466,125 on May 18, 2026, under CFDA 93.172 (Human Genome Research) to support cross-species analysis of regulatory genomic function using synthetic regulatory genomics. The award funds development and application of the BIG-IN genome engineering technology to characterize regulatory DNA function across a phylogenetic tree. The recipient will analyze model genomic loci in mouse embryonic stem...
- The National Institutes of Health National Human Genome Research Institute awarded Sloan-Kettering Institute for Cancer Research $1,579,478 on September 19, 2025, under the Human Genome Research program (CFDA 93.172) to develop experimental and computational tools that extend perturb-seq into a platform for engineering cellular transcriptional states. The project aims to transform perturb-seq into a rational tool for reconstructing diverse transcriptional states in vitro using combinatorial...
- The National Human Genome Research Institute awarded the University of California, Santa Cruz $1,243,931 on September 26, 2025, under the Human Genome Research program (CFDA 93.172) to develop new methods for studying thousands of complete human and vertebrate genomes. The recipient will scale genome alignment and analysis capabilities to accommodate approximately 10,000 vertebrate species projected to become available within four years. Work includes developing a highly scalable, automated...
- The National Institutes of Health National Human Genome Research Institute awarded the University of Washington $444,794 on May 1, 2026, under the Human Genome Research program (CFDA 93.172) to conduct molecular characterization of nuclear body assembly and pathological misassembly. The award funds research into how three-dimensional nuclear architecture regulates genomic functions, specifically examining nuclear bodies—membraneless organelles including nucleoli, nuclear speckles, and Cajal...
- The National Human Genome Research Institute awarded The Children's Hospital of Philadelphia $863,248 on February 1, 2026, under the Human Genome Research program (CFDA 93.172) to investigate three-dimensional chromatin architectural dynamics at ultra-high resolution as it relates to genome folding and gene activity. The research examines how microcompartments between active cis-regulatory elements form as cells exit mitosis and enter G1 phase, using ultra-high resolution region capture...
- The National Institutes of Health National Human Genome Research Institute awarded Yale University $2.618 million on July 6, 2026, under the Human Genome Research program (CFDA 93.172) to develop advanced computational tools for de novo genome assembly and assembly-based genomic analysis. The project, titled "Toward Comprehensive Genomic Analysis Through De Novo Genome Assembly," will produce three deliverables. First, the recipient will develop a real-time assembly algorithm that...
- The National Institutes of Health National Human Genome Research Institute awarded the University of Washington $796,114 on September 1, 2026, under the Human Genome Research program (CFDA 93.172) to develop a single-cell multi-omics toolkit for studying genome structure and function. The award funds expansion of GAGE-SEQ, a scalable single-cell multiomics method, to simultaneously profile three-dimensional genome organization and transcriptome alongside chromatin accessibility, transcription...
The National Institutes of Health National Human Genome Research Institute awarded Cytoterra Inc. $296,543 on September 1, 2026, under the Human Genome Research program (CFDA 93.172) to develop an NGS-based method for detecting Robertsonian translocations, which are whole-arm fusions between acrocentric chromosomes and among the most common large structural rearrangements in humans yet remain challenging to identify with current high-throughput genomics techniques. The project integrates distal junction copy number analysis with genomic proximity mapping (a Hi-C-based structural variant detection approach) to overcome the detection challenge posed by the highly repetitive nature of acrocentric chromosome p-arms. The method modifies reference genomes to mask endogenous distal junction sequences and introduces an artificial distal junction contig, enabling accurate copy number estimation while maintaining compatibility with clinical-grade genome assemblies. Combined with proximity ligation data, the approach will infer both the presence and identity of fused acrocentric chromosomes, closing a gap in scalable NGS diagnostics and enhancing the clinical utility of genomic proximity mapping for cytogenetics replacement. Performance occurs in Seattle, Washington with a period of performance from September 1, 2026, through August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $296.5k | 9/1/26 |