Project Grant R43HG014743
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded Evizia Inc. a $1,234,692 project grant on April 7, 2025. The grant supports the development of a novel biomolecule desktop imaging system called PRECYSE, which uses high-speed atomic force microscopy (HSAFM) to provide improved quality control for next-generation sequencing (NGS) sample preparation. The PRECYSE system can rapidly size DNA samples from 100 base...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...
- The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
- Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research CFDA 93.172 federal grant program, awarded a $1,020,280 Project Grant to Vellum Biotechnology, Inc. to develop a new nucleic acid extraction technology to enable high-quality DNA sequencing for formalin-fixed paraffin-embedded tissue (FFPET) samples. This project aims to address challenges in obtaining consistent quality and yield of purified nucleic acids from FFPET samples, which are widely used in diagnostic...
- The National Human Genome Research Institute (NHGRI), under the Federal Grant Program for Human Genome Research (CFDA 93.172), awarded a $397,599 Project Grant to Xgenomes Corp. in Cambridge, MA. The grant supports the development of a novel epigenetic analysis method that can directly detect DNA methylation patterns across the genome with high accuracy, overcoming limitations of current sequencing techniques. The project aims to create advanced molecular analysis platforms that leverage machine...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $383,748 project grant to Jumpcode Genomics Inc. The grant supports the development of a CRISPR-based depletion technology to resolve pseudogene contamination in next-generation sequencing (NGS)-based genetic testing, with a focus on improving newborn screening (NBS) clinical tests. The goal is to enhance the sensitivity and specificity of detecting disease-causing...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $396,170 project grant to Syntaxisbio Inc. on September 17, 2025. The grant supports the development of an innovative technology using genetic PUFs (Physical Unclonable Functions) to precisely quantify the age and division/passage history of cell lines. This technology aims to address the critical challenge of reliable cell line identification and validation in...
- The National Human Genome Research Institute (NHGRI) awarded a $470,637 Project Grant on April 4, 2025 to President and Fellows of Harvard College, doing business as Harvard Medical School, for the "SELF-EVOLVR: SELF-REFRESHING MOLECULAR BARCODES USING CRISPR-SELF-GUIDED MUTAGENESIS" project. The project aims to develop a new self-refreshing DNA barcode technology called "SELF-EVOLVR" to enable high-resolution lineage tracing across various biological systems. The research...
- This federal Project Grant award of $1,350,896, awarded on January 1, 2025 by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), supports the development of a multimodal massively parallel reporter assay (MPRA) platform to study regulatory sequence function. The overarching goal is to create tools that can elucidate the mechanisms and grammar by which regulatory elements in the genome encode interactions between chromatin, regulatory...
The National Human Genome Research Institute (NHGRI) awarded a $291,232 Project Grant to Micropure Genomics Inc. on September 17, 2025 under the Human Genome Research Federal Grant Program (CFDA 93.172). The project aims to develop an automated, bead-less, and gel-less microfluidic size selection approach to simplify workflows, reduce costs, and enhance the performance of long-read DNA sequencing technologies such as PacBio and Oxford Nanopore. The proposed innovation, called mPREP, leverages patented electro-hydrodynamic (EH) trapping technology to enable gentle purification and microfluidic handling of DNA samples without beads, reducing sample degradation. This solution is expected to reduce sample preparation time by over 50%, costs by over 30%, and complexity by over 90%, while improving accuracy. The project seeks to extend mPREP's capabilities to specifically support PacBio long-read sequencing, with the ultimate goal of expanding the adoption of long-read sequencing and advancing genomic research and clinical applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $291.2k | 9/17/25 |