Project Grant R43HG014149
- This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) is focused on developing and applying machine learning-based approaches to estimate disease risk in diverse and admixed populations. The $399,156 award to Galatea Bio Inc., a minority-owned small disadvantaged business located in Miami Lakes, FL, will support the following key objectives over the project period from September 2024 to August 2025: Evaluating the performance of existing...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
- This Cooperative Agreement award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $3,103,253 to The General Hospital Corporation (Massachusetts General Hospital) to develop machine learning and AI tools to enhance the prediction of disease manifestation in individuals with pathogenic genetic variants. The project, titled "PRISM: ETHICALLY-GUIDED MULTIMODAL AI MODELS FOR PREDICTING DISEASE PATHOGENESIS IN INDIVIDUALS WITH PATHOGENIC...
- This Project Grant award of $240,647 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research by Brigham & Women's Hospital Inc. to develop deep learning methods for resolving uncertain variant classifications from genomic sequencing data. The project aims to use clinical reports and variant data from the ClinVar database to train text classification models that can better predict pathogenicity of genetic variants. This will enhance the...
- The National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) awarded a $550,810 Project Grant to the University of California, Irvine (UCI) to develop an innovative AI-assisted Laser Capture Microdissection (AI-LCM) approach for spatial transcriptomics. This method aims to provide high-throughput, comprehensive spatial transcriptomics analysis with single-cell resolution and genome-wide coverage. The key products/services include: Optimizing in situ generation and...
- The National Human Genome Research Institute (NHGRI), under the CFDA program 93.172 Human Genome Research, awarded a $1,100,866 Project Grant to the Icahn School of Medicine at Mount Sinai. The grant, awarded on April 8, 2025, is to develop new methods using deep learning to predict disease risk for individuals harboring rare monogenic risk alleles. The goal is to refine the accuracy of genetic diagnostics and increase the clinical usefulness of genetic information. The project will leverage...
- This Project Grant award, valued at $161,400.00 and running from September 23, 2024 to August 31, 2026, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research federal grant program (CFDA 93.172). The award will support research to empirically validate one or more standards-based models that can help make permissions for biospecimen sharing and reuse understandable to machines. This innovative research aims to respect and protect biospecimen...
- This Project Grant award of $400,627.00, made on August 8, 2025 by the National Institute of Environmental Health Sciences under the Medical Library Assistance program (CFDA 93.879), aims to develop and test a "HealthCoach" chatbot in English and Spanish. The chatbot will help patients with varying literacy levels gain insights from their electronic health record notes and use this knowledge to prepare for their next medical visit. The award was made to Beth Israel Deaconess Medical...
- This federal Project Grant award for $1,312,212 from the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) program will support research to develop an advanced DNA language model. The primary goal is to use natural language processing techniques to better understand the role and functionality of DNA sequences, especially non-coding regions, which could lead to advancements in areas like genetic testing and personalized medicine. The...
- This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $716,587 to Boston Children's Hospital to advance equity in rare disease genomic research. The key objectives are to: Develop and implement a Diversity, Equity, and Inclusion toolkit within the Broad Institute's Rare Genomes Project to improve engagement and participation from historically underrepresented populations in rare disease genomic studies. This will involve...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $400,618 to Care Progress LLC to develop an AI-powered chatbot tool that will enhance guideline-concordant genetic e-consults for primary care physicians (PCPs). The key products to be delivered include: Methods to integrate large language models with clinical genetics practice guidelines to generate semi-automated, quality e-consult recommendations for PCPs on when to order genetic tests and request genetics consultations. This will address the challenge of PCPs lacking time and expertise to stay current on evolving genetics guidelines. A prototype web-based chatbot tool built using user-centered design principles, which will be tested for usability with PCPs. This tool aims to help PCPs make more informed clinical decisions on genetics-related care for their patients. The award period runs from September 2025 through August 2026, with a focus on advancing computational genomics and developing innovative informatics solutions to improve the application of genomics in clinical practice.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.6k | 9/20/25 |