Project Grant R43HG013914

Award Date 6/1/25
Completion Date 2/28/26
Dollars Obligated $398K
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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The Project Grant award R43HG013914, in the amount of $397,599.00, was provided by the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172). The grant supports the development of a novel epigenetic analysis platform by Xgenomes Corp., a minority-owned for-profit company based in Cambridge, MA.

The project aims to develop a single-molecule technology that can accurately detect DNA methylation patterns across the genome. This approach leverages repetitive binding kinetics of short, fluorescently-labeled probes to enable precise determination of methylation status, addressing limitations of current methods like bisulfite sequencing. The two-year project will optimize the probe chemistry and buffer composition, then refine, validate, and demonstrate the epigenetic sequencing platform in comparison to existing technologies. This innovative work has the potential to significantly improve epigenetic analysis capabilities, with applications in biomedical research and clinical diagnostics.

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