Project Grant R43HG011217

This Project Grant award from the National Institutes of Health's National Human Genome Research Institute provided $768,678 to Molecular Assemblies, Inc. to develop a fully enzymatic oligonucleotide synthesis cycle using engineered template-independent polymerases and a novel phosphate dNTP blocking group. The award supports the goals of the Human Genome Research program (CFDA 93.172) to accelerate genome research and its application to human health. Specifically, the awardee will engineer...

The National Cancer Institute (NCI) awarded a $400,000 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to Electronic Biosciences, Inc., a small biotechnology company in San Diego, California. The grant supports the development of a novel nanopore-based sequencing technology capable of accurately characterizing repetitive DNA sequences, which are known to play a significant role in cancer progression but have been challenging to analyze using current...

This $1,250,000 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of an innovative platform for preparing DNA samples for long-read sequencing technologies. The project, led by Micropure Genomics Inc., aims to resolve critical barriers in genomic sequencing by advancing an automated platform for high-quality DNA sample preparation. Key objectives include fabricating user-friendly...

The National Institute on Aging (NIA) awarded a $1,274,993 Project Grant (CFDA 93.866 - Aging Research) to Epicypher, Inc. to develop a new genomic platform called "Reverse Transcribe & Tagmentation (RT & TAG)" for analyzing chromatin-associated RNAs and nascent transcripts. This technology aims to enable high-throughput characterization of long non-coding RNAs, nuclear RNAs, and other chromatin-associated transcripts that are relevant to aging and age-related diseases like...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short DNA sequence segments or "words" by measuring the kinetics of oligonucleotide probe binding. This approach is expected to significantly improve sequencing...

Armonica Technologies, Inc. was awarded a $1,047,600 Project Grant from the National Human Genome Research Institute of the Department of Health and Human Services to develop a novel DNA sequencing platform. The award was made under the Human Genome Research program (CFDA 93.172), which supports technologies to accelerate genomic research and its application to human health. Specifically, Armonica will use the funding to optimize a metal-insulator-metal structure for single base sensitivity...

Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...

This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) will provide $649,999 to Northwestern University to develop a new label-free nanoimaging platform called 3D DNA Spectroscopic Photon-Localization Intrinsic-Contrast Nanoscopy (3D DNA-SPIN). The goal is to image the genome of intact fixed cells in 3D with 2-nanometer resolution, providing chemical and molecular information without the need for fluorescent labels. The project aims to 1) develop...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $350,000 to Electronic Biosciences, Inc., a small biotechnology company, to develop a novel technology for high-accuracy sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A). The project aims to merge the company's nanopore-based sequencing platform with innovative bisulfite adduct methodology...

The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...