Project Grant R43HG010603

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $302,605.00 to Chimerna Therapeutics, Inc. to develop synthetic biology approaches for bio-orthogonal labeling of circular RNAs. The key objectives are to: 1) optimize a bacterial strain and expression conditions for high-efficiency amino functionalization of circular RNAs, and 2) produce a variety of...

This $256,000 National Science Foundation Engineering grant supports the development of an easy RNA adenylation method for deep sequencing of picogram RNA samples with high resolution. Specifically, Ezrabio Inc. will develop a versatile and cost-effective library construction technology that enables protein translation monitoring on a variety of biological samples. The proposed technology relies on a novel enzyme system capable of 5' adenylation and 3' polyadenylation of RNA fragments to...

Electronic Biosciences, Inc. received a $350,000 Phase I Small Business Technology Transfer (STTR) project grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on June 1, 2025, with a completion date of May 31, 2027. The company, in collaboration with Distinguished Professor Cynthia J. Burrows, is developing the first high-accuracy sequencing technology capable of simultaneously detecting...

The Alida Biosciences Inc. was awarded a $765,105 Project Grant from the National Institutes of Health National Human Genome Research Institute under the Human Genome Research federal grant program (CFDA 93.172) on August 17, 2021 to complete work by February 28, 2022. The grant funds the development of a new approach to analyze RNA modifications across entire transcriptomes in a multiplexed reaction at near single-base resolution. Currently available methods either lack sequence context or...

Federal Cooperative Agreement Summary Chromologic LLC received a $533,384 Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 2, 2025, with completion targeted for August 31, 2030. The award funds the validation and advancement of the MIDOS assay, a microRNA (miRNA)-based predictive diagnostic tool designed to pre-symptomatically identify patients at risk for...

Federal Project Grant Award Summary Molecular Instruments, Inc. received a $306,788 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 30, 2025, with completion scheduled for September 29, 2026. The award supports the development and advancement of probe technology for ultrasensitive RNA imaging utilizing hybridization chain reaction (HCR) mechanisms. This research addresses...

Federal Grant Award Summary: SPINSEQ Project Electronic Biosciences, Inc. received a Phase I Small Business Innovation Research (SBIR) Project Grant of $383,482 from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded on June 6, 2025, with a completion date of May 31, 2027. The company is developing SPINSEQ, an innovative RNA sequencing platform designed to deliver precise and accurate transcriptomic analysis while preserving RNA...

Federal Project Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $445,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on June 1, 2025, with a completion date of April 30, 2030. This Maximizing Investigators' Research Award (MIRA) funds research to develop and advance long-read transcriptomics technologies for elucidating transcriptome...

This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...

This four-year, $822,736 project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program will fund research into the role of extracellular RNA in intercellular and interkingdom communication. Led by Clemson University, the collaborative project brings together seven laboratories to advance understanding of how RNA secreted by host cells maintains healthy microbiomes in plants, insects, and humans. The researchers will investigate...