Project Grant R43HG009578

The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...

The Project Grant award R43HG013914, in the amount of $397,599.00, was provided by the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172). The grant supports the development of a novel epigenetic analysis platform by Xgenomes Corp., a minority-owned for-profit company based in Cambridge, MA. The project aims to develop a single-molecule technology that can accurately detect DNA methylation patterns across the genome. This...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will develop a novel nanopore-based sequencing technology capable of accurately and simultaneously detecting the RNA modifications pseudouridine (Ψ) and N6-methyladenosine (m6A). The $350,000 award, spanning June 2025 to May 2026, is a collaborative effort between academia and industry, with Electronic Biosciences, Inc. serving as...

Armonica Technologies, Inc. was awarded a $1,047,600 Project Grant from the National Human Genome Research Institute of the Department of Health and Human Services to develop a novel DNA sequencing platform. The award was made under the Human Genome Research program (CFDA 93.172), which supports technologies to accelerate genomic research and its application to human health. Specifically, Armonica will use the funding to optimize a metal-insulator-metal structure for single base sensitivity...

The National Cancer Institute (NCI) awarded a $400,000 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to Electronic Biosciences, Inc., a small biotechnology company in San Diego, California. The grant supports the development of a novel nanopore-based sequencing approach to accurately characterize repetitive DNA sequences, which are critical for understanding cancer progression but challenging to analyze using current sequencing-by-synthesis methods. The...

This $257,807 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will develop living biosensors capable of detecting and analyzing DNA at the single-base level without requiring sample purification or specialized equipment. The biosensors will pull in DNA from raw samples, analyze it using their CRISPR-Cas systems, and produce a...

This federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a revolutionary DNA sequencing platform by Xgenomes Corp. The goal is to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual DNA bases, enabling high-density sequencing with greater accuracy and lower costs than existing methods. The $384,418 award will fund a...

The National Human Genome Research Institute (NHGRI) awarded a $409,699 Project Grant (CFDA 93.172 - Human Genome Research) to the Regents of the University of Michigan on July 1, 2024. The grant, titled "INTEGRATING LC-MS/MS AND NANOPORE SEQUENCING PLATFORMS TO ENABLE THE DIRECT AND QUANTATATIVE DETECTION OF RNA MODIFICATIONS", will support research to develop methods for the quantitative detection of RNA modifications using a combination of liquid chromatography-tandem mass...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $204,688 to The Johns Hopkins University to develop innovative sequencing technologies to study DNA ADP-ribosylation, an under-researched DNA modification with critical implications for processes like DNA repair and pathogen defense. The project aims to create two complementary sequencing techniques: one using...

Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...