Project Grant R43HG009239

Armonica Technologies, Inc. was awarded a $1,047,600 Project Grant from the National Human Genome Research Institute of the Department of Health and Human Services to develop a novel DNA sequencing platform. The award was made under the Human Genome Research program (CFDA 93.172), which supports technologies to accelerate genomic research and its application to human health. Specifically, Armonica will use the funding to optimize a metal-insulator-metal structure for single base sensitivity...

The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...

This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), provides $400,000 in funding to Electronic Biosciences, Inc. to develop a novel nanopore-based sequencing approach capable of accurately characterizing repetitive DNA sequences. The project aims to address limitations of current sequencing-by-synthesis methods in accurately sequencing genomic repeats, which are known to harbor variations associated...

This Project Grant award of $435,054 from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports an integrated research and education approach to address fundamental and applied challenges in solid-state nanopore-based single molecule counting platforms for point-of-care nucleic acid testing. The research aims to develop a fully integrated solid-state nanopore digital counting system for decentralized nucleic acid testing applications ranging from infectious disease...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...

This National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) Federal Grant Program (CFDA 47.070) award of $1,200,000 provides funding to the University of California, Berkeley from October 1, 2024 to September 30, 2028 to develop innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics. The key objectives of this project grant are to: (1) develop molecular engineering techniques using DNA origami...

The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...

This five-year, $275,000 Project Grant from the National Science Foundation's Integrative Activities program (CFDA 47.083) will support the development of a single walled carbon nanotube sensor system to simultaneously quantify hydrogen peroxide and nitric oxide concentrations. The grantee, the University of Nebraska, will develop a sterile platform to identify the extracellular concentration profiles of these reactive oxygen and nitrogen species associated with breast, skin, and lymphocyte...

This Project Grant from the National Science Foundation's $287,403 Engineering program will fund research at Southern Methodist University from March 2021 through February 2024. The University will develop ultrasensitive nucleic acid sensing tools based on Cas assays and solid-state nanopores. The Engineering program aims to improve quality of life and economic strength through innovative engineering research and education. This award supports those goals by advancing technologies for rapid,...

This $495,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research at Rice University to investigate and control the properties of single-wall carbon nanotubes functionalized with guanine-linked DNA. Principal Investigator Robert Weisman and his team will conduct experiments and computations to further explore the nature and potential applications of these nanotube-DNA hybrid structures. Specifically, the work will deepen...