This $725,077 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA Program 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research", is aimed at reprogramming intestinal immunity in preterm neonates to prevent and cure necrotizing enterocolitis (NEC), a severe and often fatal intestinal disease. The primary awardee, the University of North Carolina at Chapel Hill, will leverage its extensive NEC...
This Project Grant award, R01HD116839, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $2,024,790 award will fund research conducted by the Research Institute at Nationwide Children's Hospital (RINCH) to develop a novel probiotic delivery system to prevent and treat neurodevelopmental impairment in premature infants. The key objectives are to: 1) determine the extent...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $300,000 Project Grant to Siolta Therapeutics Inc. on August 14, 2023. The purpose of this grant is to develop STMC-106, a multistrain live biotherapeutic product (LBP), for the prevention and treatment of necrotizing enterocolitis (NEC) in preterm infants. The key objectives of this project are: 1) to identify combinations of therapeutic...
The National Institute of Child Health and Human Development (NICHD) awarded a $398,750 Project Grant (CFDA 93.865) to the University of Oklahoma (OU) to conduct research on the role of creatine metabolism in necrotizing enterocolitis (NEC), a serious gastrointestinal disease affecting preterm infants. The research aims to test the hypotheses that creatine deficiency detrimentally affects preterm infant intestinal epithelial injury, while creatine supplementation can prevent NEC-like injury. The...
This $171,728 federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to define the role of premature infant gut microbiome dysbiosis in mediating immune development and response to respiratory syncytial virus (RSV) infection. The primary goals are to investigate how the altered gut microbiome in premature infants affects their ability to...
This $630,847 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research at Children's Mercy Hospital in Kansas City, Missouri to investigate the role of the SIGIRR gene in regulating intestinal barrier function and preventing necrotizing enterocolitis (NEC) in preterm infants. The research aims to: 1) Determine how SIGIRR regulates adherens and tight junction assembly in the neonatal intestine, 2) Evaluate if SIGIRR inhibits the...
This federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), will support the development of a high-throughput in vivo screening platform using the nematode Caenorhabditis elegans to identify novel probiotic and postbiotic bacterial strains. The $295,780 award to Nemalife Inc., a for-profit biotechnology company, will fund the establishment of a...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of an FDA-approved AI-driven Total Parenteral Nutrition (TPN) platform for cost-effective and personalized nutrition for premature newborns in Neonatal Intensive Care Units (NICUs). The key objectives are to: 1) Develop a set of standardized TPN units that can be centrally...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $412,500.00 in funding to the University of South Florida (USF) to conduct a longitudinal study of gut dysbiosis in anemic preterm infants. The goal is to determine the hematocrit threshold associated with gut microbiome changes and how anemia development influences the microbiome and host interactions...
The federal Project Grant award, R43HD115494, was granted by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $296,351 award supports Brooklyn Innoseq Inc. (doing business as Mamome) in developing and validating a non-invasive microbiome-based diagnostic tool for the early detection of gestational diabetes mellitus (GDM). The project aims to identify microbial biomarkers associated...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a novel probiotic formulation specifically designed for preterm infants to prevent necrotizing enterocolitis (NEC). The $349,759 award to Vitakey Inc. will fund the expansion of a patented encapsulation technology to protect probiotic strains, Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019, for improved gastric stability and shelf life when incorporated into infant formula powders. This project seeks to create the world's first probiotic product tailored to the unique gastrointestinal needs of premature infants, addressing the variability and inconsistent results observed with current probiotic interventions for NEC prevention.