The Project Grant award R43GM156169 for $306,852.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop and validate cryopreservation technology that automates the soaking, cooling, and warming of small biological samples such as oocytes and embryos. The key objectives are to optimize convective heat transfer to achieve ultra-fast cooling and warming rates, eliminate ice formation and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $309,251 to Expanse Bio LLC to develop an ex vivo microfluidic organ perfusion device for long-term culture and assessment of whole ovaries. The goal is to create a more physiologically relevant model for evaluating the ovotoxicity (ovarian damage) potential of drug candidates, particularly...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $940,821 to Cryocrate LLC, a for-profit limited liability company based in Columbia, Missouri. The funding supports the establishment of a first-in-class, biocompatible, and efficient cryopreservation technology platform for cell-based therapeutics in regenerative medicine and drug discovery. The key products and services to be delivered include: (1) achieving...
This federal Project Grant award of $248,999.00 from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 (Child Health and Human Development Extramural Research) aims to investigate the mechanisms behind temperature-sensitive meiotic chromosome structures in male infertility. The principal investigator will leverage the Caenorhabditis elegans model system to dissect the sexually dimorphic nature of the synaptonemal complex (SC) and examine how these...
The National Institute of Child Health and Human Development (NICHD) awarded a 5-year, $674,095 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Baylor College of Medicine to develop a novel imaging technology to directly observe and better understand multiple aspects of fertilization within the mouse fallopian tube in vivo. The project will integrate expertise in live functional optical imaging and reproductive biology to perform the first in vivo tracking...
This federal Project Grant award for $165,672, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to transform newborn care by investigating the impact of hypothermia on infant outcomes and resource utilization in newborn nurseries. The principal investigator, Dr. Rebecca Dang, will lead a multi-institutional study across 8 university-affiliated nurseries to: 1) analyze...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $786,672 to the Smithsonian Institution to investigate the physiological significance of follicular extracellular vesicle microRNAs and their potential therapeutic application in oocyte vitrification. The key products and services to be delivered under this 5-year award include: 1)...
This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program, supports research to elucidate the molecular and cellular mechanisms regulating the formation of primordial follicles in the mouse ovary. The total funding amount is $596,750, with an award date of July 15, 2024 and a completion date of June 30, 2026. The key objectives of the research are to: 1)...
The National Institute of Child Health and Human Development (NICHD) awarded a $154,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The University of Kentucky Research Foundation to investigate the role of long non-coding RNAs (lncRNAs) in the ovulatory process. The research aims to identify the top 5 most highly LH/HCG-regulated lncRNA candidates and characterize their function in the ovary, specifically their role in the ovulatory...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $302,037 to Tissue Testing Technologies LLC to develop an ice-free vitrification and nanowarming method for preserving meniscal grafts used in transplantation. The project aims to optimize nanowarming techniques to maintain cell viability, gene expression, and extracellular matrix integrity...