A metabolomics-based laboratory developed test to improve the diagnostic precision of polycystic ovary syndrome

Ended Project Grant Awarded Last action

Award ID
R43HD114271
Recipient
Awarding agency
Obligated
$297,666

Award facts

Completion date
Place of performance
North Carolina, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Polycystic ovary syndrome (pcos) is a complex, multifactorial endocrine disorder characterized by hyperandrogenism, chronic anovulation, and polycystic ovaries. IT is currently diagnosed by the rotterdam criteria, which categorizes the presentation of these basic symptomologies into four main phenotypes labeled a, b, c, and d. While these phenotypes can define disease and inform clinical decision making in a broad sense, our ability to select the best precision treatments and appropriate cohorts for clinical trials remains limited because there is considerable heterogeneity within phenotypes and little data by which to define them with higher precision. Defining pcos phenotypes with higher precision to thereby improve patient outcomes starts by incorporating additional, evidence-based diagnostic criteria into present day diagnostic guidelines. In this phase i sbir, we will address the need for greater precision by testing the hypothesis that using metabolomics data in conjunction with clinical symptoms can define pcos phenotypes with higher precision than clinical symptoms alone. Metabolites are the small molecule intermediates and products of metabolism upon which the inputs from the genome, the environment, and lifestyle factors converge. Given their unique position in the central dogma of biology they are considered to be the closest reflection of an individual's real-time health status. Metabolites reflect disease activity through changes in their abundance, which can be quantified using ultra-high performance liquid chromatography and tandem mass spectrometry (uhplc-MS/MS). When used in an untargeted manner, uplc-MS/MS can measure the entire collection of metabolites in a given biological sample (the metabolome), enabling broad screening of an individual's biochemical profile to identify disease-causing metabolic perturbations (metabolic signatures of disease). We and others have shown that metabolic signatures associated with pcos can provide deep phenotypic insight into disease activity. In collaboration with DR. Richard legro at penn state medical school, metabolon will leverage its proprietary uhplc-MS/MS platform, ngptm, to interrogate metabolic signatures unique to pcos phenotype a and phenotype b and utilize high level statistical analyses to determine whether metabolic profiling can identify novel, clinically relevant sub-phenotypes and thereby define phenotypes more precisely than clinical symptoms alone. In success, the findings of this project will justify a follow-up study in which we develop a diagnostic test that targets these phenotype-defining metabolic signatures. The ultimate outcome of a successful phase i will be the development of a tool that allows pcos phenotypes to be defined more precisely than today's diagnostic guidelines, which represents a step towards improving clinical decision making, patient stratification in clinical trials, and overall patient outcomes.

Transactions

Action Obligated Date
Amendment $0
Original award $297,666

Quick answers

Who received award R43HD114271?

R43HD114271 was awarded to Metabolon, Inc. by National Institute of Child Health and Human Development (National Institutes of Health) on September 18, 2023.

How much is award R43HD114271 worth?

$297,666 has been obligated on R43HD114271.

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