Project Grant R43GM161151
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $303,024 to Biocognon LLC to develop an innovative combinatorial pipeline for discovering nanobody-based therapeutics targeting G-protein coupled receptors (GPCRs). The key products and services to be delivered under this award include: (1) developing a robust assembly system for GPCR and nanobody libraries, (2) building a...
- This Project Grant award of $306,872.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to develop a new 3D shape matching methodology that accounts for water molecules when comparing ligands during drug discovery. The key products and services to be delivered include: Adapting an existing algorithm (WATGEN) to predict water positions in unbound proteins and protein-ligand complexes, and calculate...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $218,622 Project Grant to Vitan-Biotech LLC on September 22, 2023 under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund the development of an integrated pipeline to rapidly discover and characterize selective, high-affinity nanobodies against defined G protein-coupled receptors (GPCRs) that are important for neurological disorders like schizophrenia, pain, Parkinson's, Alzheimer's, and...
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $221,448 project grant to the Massachusetts Institute of Technology (MIT) on May 15, 2025. The grant supports the development of peptide catalysts for stereo- and site-selective carbon-carbon bond formation using automated fast-flow peptide synthesis and machine learning. The research aims to leverage MIT's expertise in areas such as molecular...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $202,274 to develop an easy-to-use computer program for predicting the structure and degrading efficiency of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional molecules that induce the degradation of target proteins by recruiting them to E3 ubiquitin ligases. The awarded project aims to implement a...
- This Phase 1 SBIR Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), provides $306,872 to Peptiforge, Inc. to establish a platform for rapid development of therapeutic protein binders. The grant aims to synthesize test libraries of therapeutic protein scaffolds and evaluate the feasibility of Peptiforge's platform for accelerating the discovery of protein binders that can target...
The National Institute of General Medical Sciences (NIGMS) awarded a $202,467 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Acpharis, a biotechnology software company based in Holliston, Massachusetts. The grant supports the development of a commercial-quality software product that integrates machine learning with physics-based computational approaches to accurately predict the structures of antibody-antigen complexes. This breakthrough technology, demonstrated through Acpharis' performance in the 2024 CASP16 protein structure prediction contest, has the potential to significantly advance research and development in areas such as cancer, infectious diseases, and drug discovery. The project aims to further test and optimize the software protocol, which is based on a modified version of the PIPER docking program licensed from Boston University, and deliver a final commercial product by August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $202.5k | 8/5/25 |