Project Grant R43GM157792

Award Date 4/1/25
Completion Date 3/31/26
Dollars Obligated $330K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded Trestle Optics LLC a $305,647 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop a novel photothermal microscopy system for non-destructive, high-resolution screening and sorting of microalgae to identify and enrich strains producing high-value polyunsaturated fatty acids. The project aims to engineer and prototype a microfluidic platform integrating photothermal imaging...
The National Institute of General Medical Sciences (NIGMS) awarded a $290,536 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Trestle Optics LLC, a small disadvantaged business, to develop a novel high numerical aperture catadioptric lens for ultra-broadband multimodal microscopy. This lens will enable advancements in existing nonlinear optical imaging modalities, such as three-photon excited fluorescence and third-harmonic generation, by overcoming limitations of...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of a multi-functional Plasmonic Scattering Microscopy (PSM) instrument. The PSM technology enables high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native microenvironment. This addresses an unmet...
This federal Project Grant award of $333,048.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of a 2-photon microscopy version of the "Spotlight" optical cell isolation technology by Imagen Bioworks Inc. The goal is to create a versatile platform that can isolate individual cells from three-dimensional samples after spatial and temporal profiling. This will enable research in...
This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical...
The National Institute of General Medical Sciences (NIGMS) awarded a $258,586 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to MSTM LLC, located in Newark, DE. The purpose of this 12-month Phase I project is to demonstrate the feasibility and proof-of-concept of a new surface reader technology that can remotely detect and analyze the molecular composition of surfaces, including for the early detection of infectious diseases, hazardous materials, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $304,196 to Laser Bioanalytics LLC to develop a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable matrix-assisted laser desorption ionization (MALDI) mass spectrometry structural analysis and imaging of lipids, which are important cellular components involved in...
The National Institute of General Medical Sciences (NIGMS) awarded a $275,756 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Rewire Neuroscience LLC, a woman-owned small business in Oregon. The funding supports the development of PipSqueak Pro, an AI-powered computer vision platform that aims to democratize access to advanced machine learning techniques for automated biomedical image analysis. The platform seeks to reduce human bias, subjectivity,...
The National Institute of General Medical Sciences (NIGMS) awarded a $374,399 five-year Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, Davis (UC Davis) to develop innovative two-photon microscopy systems with scattering correction capabilities for deep tissue imaging. The project aims to enable high-resolution cellular-level imaging at depths previously unattainable, through advancements in optical hardware and computational software....
The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $296,043 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Seetrue Technology, LLC, a woman-owned small business. The grant funding supports the development of mechanically robust 3D-printed microcapillary needles with anti-clogging capabilities for biomedical research and clinical applications. The project aims to create durable microneedles that can improve experimental...

The National Institute of General Medical Sciences (NIGMS) awarded a $330,076 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Trestle Optics LLC, a small business in Irvine, California. The funding will support the development of a novel photothermal microscopy platform that leverages infrared absorption spectroscopy and spatial light interference imaging to non-destructively profile metabolites in individual cells. The goal is to create a high-resolution, video-rate chemical imaging system capable of monitoring the presence of small molecules like vitamin B6 in live cells, with applications in preclinical drug development and synthetic biology research. This instrument will complement existing spatial biology technologies and provide valuable phenotypic data to evaluate lead candidates and optimize drug metabolism studies. The award period runs from April 2025 to March 2026.

Generated 4/8/25, 2:53 AM