Development of next-generation biologics programmed with multifunctional synthetic chemistries
Ended Project Grant Awarded Last action
- Award ID
- R43GM150368
- Recipient
-
Pearl Bio, Inc. UEI QRR3ELYYB486
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $549,384
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date
- Originally
- Place of performance
- Massachusetts, USA
Award details come from USAspending.gov.
Description
- Abstract
- Protein biologics constitute an important class of therapeutics owing to their high specificity, bioactivity and potential for tunability. Cytokine (CK) proteins applied as biotherapeutics show great promise for several disease indications, including cancer, multiple sclerosis, and hepatitis C infection. However, major barriers preventing the advancement and widespread clinical use of CKS to address critical public health needs include: (I) tendencies to cause systemic immune activation as a result of their on-target, off-tumor effects (II) rapid proteolytic degradation and clearance by the kidneys as small proteins (
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $274,692 | |
| Original award | $274,692 |
Quick answers
Who received award R43GM150368?
R43GM150368 was awarded to Pearl Bio, Inc. by National Institute of General Medical Sciences (National Institutes of Health) on March 1, 2024.
How much is award R43GM150368 worth?
$549,384 has been obligated on R43GM150368.
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