This $330,076 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a novel photothermal microscopy platform by Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The goal of this project is to create an advanced optical imaging system that can non-destructively profile cellular metabolites, providing critical insights for...
The National Institute of General Medical Sciences (NIGMS) awarded a $290,536 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Trestle Optics LLC, a small disadvantaged business, to develop a novel high numerical aperture catadioptric lens for ultra-broadband multimodal microscopy. This lens will enable advancements in existing nonlinear optical imaging modalities, such as three-photon excited fluorescence and third-harmonic generation, by overcoming limitations of...
The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $304,196 to Laser Bioanalytics LLC for the development of a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable improved mass spectrometry structural analysis and imaging of lipids, which are important cellular components relevant to disease diagnosis...
Trestle Optics LLC received a $256,380 Project Grant from the Department of Energy Office of Science under the Office of Science Financial Assistance Program (CFDA 81.049) to fund the Quantifying the Algal Metabolome through Photothermal Microscopy project. The grant aimed to advance understanding of algal metabolomes through the development of photothermal microscopy techniques. Trestle Optics will leverage its expertise in photothermal microscopy to develop new methods for visualizing and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...
This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical...
This Phase II Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop and commercialize Video Rate Photothermal Infrared (VR-PTIR) imaging and spectroscopy. The proposed VR-PTIR technology will provide 10-30 times better spatial resolution than conventional infrared (IR) spectroscopy and operate up to 1,000 times faster than previous photothermal IR microscope systems. The...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, provides $526,451.00 to the University of Maryland, College Park to develop a novel optical microscopy technology based on pulsed stimulated Brillouin scattering (SBS). The goal is to create a non-contact, non-perturbative, high-resolution microscopy system for probing the biomechanical properties of cells across...