Assessment of episcleral vasculature for glaucoma management
Ended Project Grant Awarded Last action
- Award ID
- R43EY032847
- Recipient
-
Vasoptic Medical, Inc. UEI FKB6UR5M6C84
- Awarding agency
-
National Eye Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $769,665
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date
- Originally
- Funding
-
- $513,110.00 Federal
- $256,555.00 Non-federal
- Place of performance
- Maryland, USA
Award details come from USAspending.gov.
Description
- Abstract
- Glaucoma is one of the leading causes of irreversible blindness globally and is caused by retinal ganglion cell death or loss associated with elevated intra-ocular pressure (IOP). Current treatment strategies revolve around reduction of IOP, but are limited by poor adherence and potentially blinding surgical complications. Microinvasive glaucoma surgery (MIGS) has offered a promising solution to reduce IOP, however results have been inconsistent in part due to the lack of real-time assessment of aqueous outflow. This has limited the success of MIGS. Our project proposes to develop an optical imaging-based solution to quantify aqueous humor outflow and blood flow in the episcleral veins to provide crucial insight to ophthalmic surgeons performing MIGS in real- time to support optimal surgical approach. During phase I, we will develop a hardware-software system for estimating flow of blood and aqueous humor, optimize and characterize its performance in vitro using standard imaging targets and flow phantoms (aim 1), and subsequently validate its performance in vivo using rabbit models of anterior segment imaging and glaucoma (aim 2). If successful, we anticipate undertaking a phase II effort comprising clinical studies to validate the clinical performance of the system before and after MIGS (aim 1) and the demonstration of improvement in outcomes of MIGS outcomes with real-time availability of feedback from our technology (aim 2). This project, thereby, aims to the lay the foundation of a data-driven approach for MIGS, or smart MIGS.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $256,555 | $0 | |
| Original award | $256,555 | $256,555 |
Quick answers
Who received award R43EY032847?
R43EY032847 was awarded to Vasoptic Medical, Inc. by National Eye Institute (National Institutes of Health) on September 1, 2021.
How much is award R43EY032847 worth?
$769,665 has been obligated on R43EY032847: $513,110 in federal funding and $256,555 in non-federal funding.
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