Aisight Health Inc. received a $479,580 Project Grant award from the National Institutes of Health's National Eye Institute to develop artificial intelligence tools to identify rapid glaucoma progression. The goal is to use machine learning models trained on over a decade of optical coherence tomography images, visual field tests, and clinical records for more than 9,000 glaucoma patients to more accurately and quickly determine which patients are likely to experience rapid vision loss from...
This $1,066,178 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports the late-stage preclinical development and GMP production of a first-in-class extended release intraocular pressure (IOP)-lowering formulation for the treatment of glaucoma. The funding will enable the awardee, Tavo Biotherapeutics, Inc. (operating as Oculo Therapy LLC), to perform the IND-enabling studies required by the FDA prior to submitting a first-in-human...
The University of Missouri System received a Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867). The $412,811 award, effective September 1, 2023 through August 31, 2025, supports the development of a novel adjustable glaucoma drainage device (AGDD) to regulate intraocular pressure. The project aims to design and fabricate a magnetically-responsive shape memory polymer composite valve integrated into a conventional shunt tube. This AGDD would...
The National Eye Institute (NEI) awarded a $713,964 Project Grant (CFDA 93.867 Vision Research) to the University of California, San Francisco (UCSF) to develop a prototype of a contact lens-based intraocular pressure (IOP) sensor using atomic force microscopy. The overall goal is to create an accurate, safe, and wearable IOP monitor that can improve the clinical management of glaucoma, the leading cause of irreversible blindness. The 5-year project aims to: 1) Develop the prototype contact lens...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $387,428 to The Research Foundation For The State University Of New York to investigate mechanisms underlying optic nerve sensitivity to elevated intraocular pressure, a major risk factor for glaucoma. The key objectives are to: 1) Determine how optic nerve head astrocytes integrate transient biomechanical strains to predispose to future glaucomatous...
This federal Project Grant award, totaling $390,000.00, was issued by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867). The grant supports a comprehensive research project aimed at assessing the biomechanical and hydrodynamic effects of different drugs and treatments on modulating outflow facility in the conventional outflow pathway of the eye. The key objectives of the project are to: 1) determine the low-flow and high-flow regions in human donor eyes using...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $628,531 to the University of Miami to validate and implement an artificial intelligence (AI) machine-to-machine (M2M) model for equitable glaucoma screening in underserved populations. The key products and services to be delivered under this 4-year grant include: Refining the M2M model using large clinic and population-based datasets, applying innovative frameworks like vision transformers and...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will provide $623,090 to Oregon Health & Science University (OHSU) from September 1, 2024 to June 30, 2029. The project aims to develop a new wide-field visible-light optical coherence tomography (WF-VIS-OCT) device optimized for the rat eye. This will enable in vivo quantification of total retinal blood flow, oxygen saturation, and vascular changes in the oxygen-induced...
The National Eye Institute (NEI) awarded a $715,098 Project Grant under the Vision Research program (CFDA 93.867) to the Massachusetts Eye and Ear Infirmary, a non-profit hospital and research center affiliated with Harvard Medical School. The grant aims to enhance glaucoma risk prediction through advanced genomics and machine learning approaches. Key objectives include: Improving polygenic risk score (PRS) performance for glaucoma by leveraging natural language processing techniques to...
The National Eye Institute (NEI) awarded a $234,000 Project Grant (CFDA 93.867 - Vision Research) to Oregon Health & Science University (OHSU) for the period of February 1, 2025 to January 31, 2027. The grant supports research to enhance stem cell restoration of intraocular pressure (IOP) homeostasis in glaucoma through the use of senolytic treatments. The project aims to leverage senotherapeutics to selectively clear senescent trabecular meshwork cells and restore IOP homeostatic...