Project Grant R43DD001299

This federal Project Grant award of $809,312 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to characterize circadian function and its implications for clinical and cognitive functioning in children with Attention-Deficit/Hyperactivity Disorder (ADHD). The study, conducted by Duke University and its subcontractor RTI International, will use gold-standard dim light melatonin onset (DLMO) assessment as well as innovative...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $826,902 to the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. to investigate the dynamic relationships between physical activity, sleep, and circadian rhythms with heterogeneity in clinical symptoms and neurobehavioral functioning in children with attention-deficit/hyperactivity disorder (ADHD). The study will leverage...

This $633,671 Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) supports research to evaluate the safety of prescription sleep medications used by children, adolescents, and young adults with ADHD. The study team at Rutgers, The State University of New Jersey will use national administrative claims data spanning 2001-2023 to examine age-specific patterns of sleep medication use and assess the risks of serious adverse events,...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will provide $181,234 to the University Enterprises Corporation at CSUSB to study the impact of preadolescent psychostimulant exposure on sleep neurophysiology and circadian rhythms in an animal model of ADHD. The goal is to break down the complex relationship between early psychostimulant use and ADHD, and whether any effects on sleep...

This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA program 93.242 - Mental Health Research Grants provides $4,698,676 to Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center, to study the association between sleep electroencephalogram (EEG) biomarkers and psychopathology risk through young adulthood. The key products and services to be delivered include: Leveraging longitudinal sleep EEG data to analyze the...

This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $399,739 to Attune Neurosciences, Inc. to develop a wearable, head-worn low-intensity focused ultrasound (LIFU) device for enhancing sleep in individuals with substance use disorder (SUD), including opioid use disorder (OUD). The key products and services to be delivered under this Phase I Small Business Innovation Research (SBIR) grant include...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will fund the development and validation of a novel wearable sensor system called "SleepTronix" to comprehensively assess sleep, breathing patterns, and circadian rhythms in individuals with obstructive sleep apnea (OSA). The $253,500 award will be used to refine the SleepTronix system, which monitors physiological signals such as EEG,...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158.00 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The goal is to create a prototype device that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, who are at elevated risk of Alzheimer's disease. Successful completion of this Phase I...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,534,832 to the University of Pittsburgh to develop accessible sleep EEG growth charts for young people. The project aims to create normative age-based reference models for sleep physiology measures in typically developing individuals aged 9-26 years using both polysomnography and a wearable sleep recording device. This research...

The National Institute of Mental Health (NIMH) awarded a $615,908 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Nurelm Inc. on August 15, 2024. The project, titled "Using Machine Learning and Sensing to Contextualize Hyperactivity Measurement on Wearable Devices", will develop and validate the LEMURDX software system, which uses smartwatch sensors and machine learning algorithms to objectively measure hyperactivity in children with ADHD. The project aims to refine...