Project Grant R43DA064569
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 15, 2025, with completion scheduled for August 31, 2027. This R21 exploratory grant funds fundamental neuroscience research investigating the neurobehavioral consequences of fentanyl overdose and their relationship to relapse risk in individuals with opioid use...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $159,615 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2025, for research extending through June 30, 2027. This K99/R00 award supports a research initiative titled "Predicting Craving and Relapse Using Neurobehavioral Markers of Goals and Habits in Opioid Use Disorder." The project delivers longitudinal neurobehavioral...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a Project Grant of $198,164 to the University of Pittsburgh under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 25, 2025, with a completion date of April 30, 2028. The grant funds research investigating Delta Opioid Receptor (DOR) regulation of parvalbumin interneuron transmission and oxycodone-related behavior in the context of opioid use disorder (OUD). The research addresses a critical...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $438,950 under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Board of Regents of the University of Nebraska, operating through the University of Nebraska Medical Center (UNMC) in Omaha. The award, made on May 1, 2026, supports an R21 exploratory/developmental research grant with a project completion date of April 30, 2028. The research investigates the mechanisms underlying polysubstance use (PSU)...
- Federal Grant Award Summary Virginia Commonwealth University received a $931,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, with completion targeted for May 31, 2030. The award supports research to develop novel mu opioid receptor (MOR) selective bitopic ligands designed to counteract the effects of synthetic opioids, including fentanyl and non-fentanyl novel synthetic opioids...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Medical University of South Carolina a Project Grant of $210,168 under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period May 1, 2026, through April 30, 2028. This award supports basic neuroscience research investigating glutamatergic neural circuit mechanisms underlying opioid use disorder (OUD) and reward-seeking behavior. The funded research dissects pathway-specific glutamatergic...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $450,175 under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Research Foundation For Mental Hygiene, Inc., through its New York State Psychiatric Institute division, to conduct a clinical research study investigating the efficacy of sphenopalatine ganglion (SPG) nerve blocks as an adjunctive treatment for opioid use disorder (OUD). The award, effective May 15, 2026, through April 30, 2028, funds...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2027. The award supports development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) methodology to characterize the functional role of cis-regulatory elements and genetic variants associated with substance use disorders. Specifically, the...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $787,594 under the Drug Use and Addiction Research Programs (CFDA 93.279) for research on the cortical mechanisms of opioid reinforcement. The award, effective September 1, 2025, through May 31, 2030, supports a comprehensive research program investigating the molecular, cellular, and circuit-based mechanisms underlying opioid use disorder...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Oklahoma State University Center for Health Sciences a $377,586 Project Grant on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on sex-specific sumoylation mechanisms in heroin-seeking behavior. The research will examine how post-translational protein modifications mediated by the enzyme UBC9 influence heroin addiction and neuroadaptations differently in...
Praeventix LLC received a $355,190 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period of June 1, 2026 through May 31, 2027. The award supports in vivo preclinical research characterizing 5-HT7 (serotonin 7 receptor) modulators in rat models of opioid use disorder (OUD). The research program will evaluate the impact of novel 5-HT7 antagonists, including the lead compound PRA078, which has demonstrated statistically significant reduction in cue-induced reinstatement in rat models of substance use disorder. This work is designed to generate pharmacological data and evidence supporting the development of new therapeutic candidates to address the critical unmet medical need in OUD treatment. The project addresses a significant public health priority, as opioid use disorder affects approximately 2.7 million Americans and is associated with substantial mortality and economic burden exceeding $1.5 trillion annually. The research conducted under this award will contribute to the broader NIDA mission of developing novel prevention and treatment approaches for substance use disorders through translational neuroscience research. The findings will support the advancement of PRA078 toward potential clinical development pathways and may inform regulatory submissions for further human studies.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $355.2k | 5/19/26 |