Project Grant R43DA058603

Award Date 9/30/24
Completion Date 9/29/25
Dollars Obligated $275K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
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Epivario is screening next-generation inhibitors of the metabolic enzyme ACSS2, which has been shown to play a role in the encoding of drug-related memories linked to craving and relapse in OUD. The top ACSS2 inhibitor compound will be further tested in a rat model of opioid addiction to evaluate its efficacy in disrupting drug-related cue memory and associated behaviors, as well as assess any potential adverse effects on memory and learning. These experiments aim to identify a promising ACSS2 inhibitor that could be advanced as a novel pharmacotherapy for the treatment of OUD.

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