Real-time multimodal diffuse reflectance and polarization imaging based nerve identification in surgical field of view
Ended Project Grant Awarded Last action
- Award ID
- R42EB029888
- Recipient
-
Yaya Scientific LLC UEI XJ5YP74TJTN7
- Awarding agency
-
National Institute of Biomedical Imaging and Bioenginering
National Institutes of Health, Department of Health and Human Services
- Obligated
- $5,220,515
Award facts
- Assistance listing
- 93.384 ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)
- Completion date
- Originally
- Funding agency
- National Institutes of Health Department of Health and Human Services
- Place of performance
- Tennessee, USA
Award details come from USAspending.gov.
Description
- Abstract
- We propose to develop a novel non-contact, label-free multimodality imager that provides real-time intraoperative identification of nerves within the surgical field-of-view to facilitate the prevention of unintended nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical complications, e.g., chronic pain. In the united states chronic pain management is a major putative contributing factor in the current opioid-related drug overdose epidemic. Annually, over 45 million surgical procedures are performed in the united states and an estimated 10% to 50% of them result in patient chronic postoperative pain outcomes. Though not all the at least 4.5 million are definitively ascribable to iatrogenic nerve injury, IT nonetheless represents a significant recurring annual healthcare problem. Relatedly, analysis of large-scale nerve lesion treatment studies reveals that 25%, 60% and 94% respectively of sciatic, femoral and accessory nerve lesions addressed are caused by iatrogenic nerve injury. Additionally, iatrogenic nerve injury features prominently in post-surgical quality of life issues that range from loss of sensation and motor function to the aforementioned chronic pain, and morbidity. Reportedly, 2-3 years post radical prostatectomy ~60% of men are still impotent as a result of damaged cavernous nerves. Likewise, 20% - 60% of mastectomy breast cancer treatment survivors suffer chronic post-surgical pain that significantly reduces their quality of life, and injury to the intercostobrachial nerve is the primary cause. Even in surgeries with minimal neural damage risk like acoustic neuroma removal (
Transactions
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| Amendment | $0 | |
| Amendment | $1,111,771 | |
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| Amendment | $998,991 | |
| Amendment | $998,991 | |
| Original award | $998,991 |
Show all 15
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Vanderbilt University Medical Center | $11,994 | |
| The Johns Hopkins University | $122,813 |
Quick answers
Who received award R42EB029888?
R42EB029888 was awarded to Yaya Scientific LLC by National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) on September 21, 2020.
How much is award R42EB029888 worth?
$5,220,515 has been obligated on R42EB029888.
Which agency awarded R42EB029888?
National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) awarded R42EB029888, with funding from National Institutes of Health (Department of Health and Human Services).
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