This $671,310 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of novel therapeutic agents for the treatment of Stimulant Use Disorder (STUD). The awardee, Verisim Life, Inc., is leveraging its proprietary AI-driven drug discovery platform, BioiSim, to expedite the development of STUD drug candidates with favorable pharmacokinetic, pharmacodynamic, and safety profiles. The key goals of this 3-year project are to: 1) expand BioiSim's AI capabilities to predict drug effects on the ghrelin-1 pathway, 2) utilize AI/ML for lead optimization to enhance selectivity, potency, and safety, and 3) apply AI-driven methods to predict synthesis approaches and characterize the lead compounds' preclinical pharmacological properties. By harnessing advanced AI technologies, this project aims to deliver a drug candidate ready to proceed to the pre-IND stage by the end of the award period in July 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $671.3k | 7/16/25 |