Project Grant R41TR004320
- The National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $707,410 project grant to Duke University to address inequities in pulse oximetry related to skin tone. The "Overcoming Inequities in Pulse Oximetry Through Clinical Informatics (OPTIC)" project aims to develop machine learning models to predict which patients are at high risk for "hidden hypoxemia" and identify those who would benefit from...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) totaling $134,537 aims to pioneer a novel, non-biased pulse oximetry method for assessing arterial oxygen saturation. The research project seeks to develop a person-specific, auto-calibrated pulse oximetry approach that can more accurately determine arterial oxygen levels compared to conventional methods, which have been shown to have positive biases for dark-skinned...
- The University of Colorado-Denver received a $234,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on addressing bias in pulse oximetry accuracy associated with darker skin pigmentation. The project aims to prospectively determine the effects of directly measured skin pigmentation on pulse oximeter performance, testing the hypothesis that darker skin pigmentation will be associated with increased pulse...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $584,575 to Emory University to develop and validate correction equations that enhance the accuracy of infrared medical devices, such as pulse oximeters and temporal thermometers, in patients with acute respiratory failure. The goal is to investigate contributors to device errors, including factors like melanin, and develop algorithms to improve the accuracy of...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $374,378 to Michigan State University to develop a computational modeling framework for a miniaturized, noninvasive, wireless, luminescence-based carbon dioxide sensing wearable device. The goal is to accurately translate transcutaneous partial pressure of CO2...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $639,165 to The Washington University to develop an "Equitable and Accessible Wearable Device for Continuous Calculation of Blood Loss for Postpartum Hemorrhage." The project aims to create a novel light-based sensor system that can noninvasively and continuously monitor cardiovascular parameters to rapidly detect postpartum hemorrhage, which is the...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop the next-generation photoacoustic computed tomography through an ergodic relay (PACTER) device for non-invasive monitoring of cerebral metabolic rate of oxygen (CMRO2). The $249,000 award to the University of Colorado, with a project period from July 1, 2025 to...
- This $254,369 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a wearable device capable of continuously sensing physiological signals for biometric authentication and health monitoring. The key products and services to be delivered under this 3-year award include: The project will explore the use of multispectral photoplethysmography (PPG) signals collected through custom-designed wearable devices for continuous biometric...
- This $449,598 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a novel wireless, noninvasive optical e-tattoo capable of continuously and simultaneously monitoring arterial and venous oxygenation. The key innovations include: (1) an ultrathin, stretchable e-tattoo with an array of photoplethysmography sensors over major artery-vein pairs; (2) algorithms to separate arterial and venous pulses and convert absorbance data into...
- This Project Grant from the National Institute for Minority Health and Health Disparities, part of the Department of Health and Human Services National Institutes of Health, provides $769,755 to develop an unbiased machine learning tool for the prediction of acute coronary syndrome. The tool aims to minimize bias in predictions between patient demographic groups, as measured by equal opportunity difference and the Zemel statistic, to ensure machine learning algorithms do not exacerbate...
NOVEL PIGMENT SENSING PULSE OXIMETER TECHNOLOGY FOR MITIGATING RACIAL BIAS IN OXYGEN SATURATION MEASUREMENTS - ABSTRACT WEARABLE PULSE OXIMETRY SENSORS ARE AMONG THE MOST UBIQUITOUS MEDICAL TECHNOLOGIES USED IN HEALTHCARE. CLINICIANS RELY ON PULSE OXIMETERS TO MONITOR PATIENT HEALTH DURING DISEASE STATES AND MEDICAL PROCEDURES. HOWEVER, NUMEROUS STUDIES HAVE SHOWN THIS TECHNOLOGY TO BE RACIALLY BIASED; HYPOXEMIA IS THREE TIMES MORE LIKELY TO GO UNDETECTED IN PATIENTS WITH DARK SKIN COMPARED TO THOSE WITH LIGHT SKIN. THIS TECHNOLOGICAL DEFICIT DISPROPORTIONATELY IMPACTS PEOPLE OF COLOR IN THE UNITED STATES AND CONTRIBUTES TO MINORITY HEALTHCARE DISPARITIES. THE FDA HAS SINCE ISSUED A SAFETY WARNING ABOUT USING PULSE OXIMETRY FOR MINORITY POPULATIONS. LOW BLOOD OXYGEN LEVELS CAN SIGNIFY SERIOUS RESPIRATORY ILLNESS IN A PATIENT AND HEALTHCARE WORKERS RELY ON PULSE OXIMETERS TO DETERMINE WHAT TYPE OF CARE A PATIENT NEEDS. FALSE NEGATIVE HYPOXEMIA DIAGNOSIS CAN HAVE DETRIMENTAL CONSEQUENCES FOR PATIENT CARE INCLUDING INCREASED RATES OF MORTALITY AND ORGAN DYSFUNCTION. THE WIDESPREAD AND IMPACTFUL USE OF THESE DEVICES HIGHLIGHTS A CRITICAL NEED FOR INNOVATIVE TECHNOLOGY THAT IMPROVES HEALTHCARE EQUITY AND MITIGATES RACIAL BIAS IN PULSE OXIMETRY. DESPITE WELL-DOCUMENTED RACIAL BIASES, A 2022 SURVEY OF PULSE OXIMETER TECHNOLOGY FOUND NO MANUFACTURERS ATTEMPTING TO INCORPORATE NOVEL TECHNOLOGY THAT ACCOUNTS FOR DIFFERENCES IN SKIN TONE. THE GOAL OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL SENSOR TECHNOLOGY FOR NON-INVASIVELY MEASURING BLOOD OXYGEN SATURATION THAT ACCOUNTS FOR THE PATIENT'S SKIN PIGMENT AND DELIVERS RELIABLY ACCURATE OXYGEN SATURATION MEASUREMENTS FOR PERSONS OF ALL SKIN COLORS. OUR PROPOSED TECHNOLOGY INCORPORATES TWO SENSING MODULES: A NOVEL SKIN PIGMENT COLORIMETRY SENSOR FOR CLASSIFYING PATIENT SKIN TONE AND AN OPTICAL TRANSDUCER FOR MEASURING BLOOD OXYGEN SATURATION VIA THE PHOTOPLETHYSMOGRAPHY TECHNIQUE. WE WILL DEVELOP A MACHINE LEARNING ALGORITHM TO MODEL AND COMPENSATE FOR THE EFFECTS OF SKIN TONE ON BLOOD OXYGEN SATURATION MEASUREMENTS. THESE INNOVATIONS IN TECHNOLOGY DEVELOPMENT AND BIOLOGICAL SIGNAL PROCESSING WILL MEET A CRITICAL NEED FOR A MEDICAL DEVICE THAT PROVIDES ACCURATE BLOOD OXYGEN SATURATION MONITORING FOR PERSONS OF ALL SKIN COLORS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | 0$ | 9/10/24 | ||
| Not listed | $0 | 6/17/24 | ||
| Not listed | $0 | 6/17/24 | ||
| Not listed | $256.2k | 12/15/22 | ||
| Not listed | $256.2k | 12/15/22 |