Project Grant R41NS115282

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $388,158.00 to the University of California, Los Angeles (UCLA) to engineer a highly active and selective gamma-Aminobutyric Acid (GABA) oxidase enzyme. The goal is to develop a high-performance, implantable, electroenzymatic GABA microsensor that can monitor GABA transients in the...

The National Science Foundation awarded AMG Detection, Inc. $305,000 on July 1, 2026, under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a wearable carbon nanotube sensor array for seizure prediction. The project aims to create the first scalable, non-invasive wearable device capable of predicting epileptic seizures 10–45 minutes before onset by detecting a validated panel of nine pre-seizure volatile organic compounds emitted from the skin. Current seizure...

This Small Business Innovation Research (SBIR) Phase I project, awarded by the National Science Foundation (NSF) under the TIP (Technology, Innovation, and Partnerships) program (CFDA 47.084), aims to develop a novel, multifunctional neural probe for advancing neuroscience research. The $254,456 grant awarded to Neurobionics Inc. on August 15, 2024, will fund the integration of electrical, optical, and chemical capabilities into a single implantable device. This versatile tool will enable...

The National Institute of Mental Health awarded Neuralthread Inc. $2.149 million on September 17, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop TULLEKIT, an integrated deep-brain neural recording system for non-human primates. TULLEKIT combines ultraflexible 384-channel polymer probes, a minimally invasive port system for deep-brain implantation, and a wireless recording headstage to achieve stable, high-density neural recordings in freely moving subjects. The...

The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $1,189,496 on April 10, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop real-time, seconds-resolved measurements of amino acid homeostasis using electrochemical aptamer-based (EAB) sensors. The project will adapt EAB sensor technology—a platform invented by UCSB researchers—to measure plasma...

This Project Grant award of $348,373 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a novel family of biosensors that can be used to report on and dynamically regulate changes in neuroinflammation within the brains of live animals. The key products and services to be delivered through this grant include: 1) Developing and...

This NSF Engineering Program award of $605,320 to North Carolina State University (NC State) supports the development of a flexible, FMRI-compatible neural probe with multi-modal sensing and modulation capabilities. The novel probe is designed to advance understanding of neural circuit dynamics and enable closed-loop neuromodulation for treating neurological disorders. Key product elements include: Flexible, multi-shank neural probe fabricated using polymeric materials to enable deep brain...

The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic...

The National Institute of Mental Health awarded $456,902 to 37Degrees, Inc. on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop INVITREON, a compact integrated platform for long-term neuronal culture incubation, recording, and closed-loop stimulation. The project runs through July 31, 2028, with performance in Chicago, Illinois. INVITREON addresses technical barriers in microelectrode array (MEA) culture systems used for disease modeling, neurotoxicity...

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $511,798 was awarded to Kilele Health Inc. on June 15, 2022 to develop continuous diagnostic monitoring platforms beyond glucose sensing. Unlike existing enzymatic glucose sensors, the company will utilize electrochemical aptamer sensors that can rapidly measure other molecules in the body with high specificity and sensitivity. The aim is to address limitations that have...