Project Grant R41HL170893

Award Date 7/15/24
Completion Date 6/30/25
Dollars Obligated $128K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Louisville, KY 40206, USA
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This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program, supports the development of an innovative urine-based diagnostic test for obstructive sleep apnea (OSA) in children. The awardee, PGXL Technologies LLC, is a minority-owned for-profit company focused on creating advanced biomarker-based diagnostic technologies.

The $128,047 award will enable PGXL Technologies, in collaboration with the University of Louisville Research Foundation, to develop a urine collection kit that can stabilize key protein biomarkers associated with OSA. This proof-of-concept work is a critical step towards validating PGXL's multiplex immunoassay panel, which preliminary data indicates can provide 100% sensitivity and 96.5% specificity for diagnosing OSA in children. The successful completion of this Phase I STTR project will advance PGXL's efforts to obtain FDA clearance for their innovative, non-invasive urine-based test, which aims to improve screening, diagnosis, and monitoring of OSA in both pediatric and adult populations.

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