Project Grant R41HD079201

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $635,386 to Duke University to conduct research on the pathogenic mechanisms of inflammatory subventricular zone injury in preterm infants. The key objectives of the research are to: 1) use single-cell and spatial transcriptomic approaches to define immune signatures associated...

This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on preventing cerebrovascular disease caused by neonatal asphyxia. The $498,595 award, with a period of performance from July 1, 2024 to June 30, 2029, will enable the University of Tennessee Health Science Center to investigate novel...

This $444,125.00 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will be used by the University of California, San Francisco (UCSF) to conduct research on the brain maturation-dependent mechanisms underlying hemorrhagic transformation after delayed reperfusion in perinatal and childhood ischemic stroke. The key objectives are to: 1)...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $231,974 Project Grant (CFDA 93.853) to Celdara Medical, LLC to develop a neuroprotective therapy for acute ischemic stroke (AIS). The project aims to demonstrate the efficacy of Celdara's lead compound, CM-EA1, in preserving neurons in the ischemic penumbra and reducing disability in AIS patients. This work will involve preclinical studies in rodent models to evaluate the therapeutic potential of CM-EA1. Celdara...

This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new therapeutic approach for neurodevelopmental mitochondrial disorders. Specifically, the $105,625 award will support research to analyze how a specific succinyl-CoA precursor is metabolized in the brain of a mouse model of pyruvate dehydrogenase deficiency (PDHD),...

This federal Project Grant award of $584,717 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the impact of intraventricular hemorrhage (IVH) on the development and restoration of the multiciliated ependymal cells lining the cerebral ventricles. The goal is to understand how IVH-induced damage to the ependyma contributes to the...

The Trustees of Columbia University in the City of New York, through its Health Sciences Division, has been awarded a $452,375 Project Grant by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). This funding will support a 2-year research project to investigate the role of cerebral pericytes in age-related vasodilatory responses to inhaled anesthetics, and the potential link to...

The National Institute of Child Health and Human Development (NICHD) awarded a $1,708,120 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Baylor College of Medicine to develop less invasive, novel intervention strategies for endogenous in utero repair of spina bifida. The project aims to create a pro-regenerative environment within the amniotic cavity to activate cellular and molecular cascades and reduce the severity of spina bifida lesions. This will...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,223,140 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Chicago. The goal of this 5-year research project is to test a novel biopharmaceutical agent called Sanguinate that is designed to boost arterial collateralization and deliver oxygen to ischemic tissue in acute ischemic stroke patients. The research aims to determine if this...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $499,953 to Stem Pharm, Inc. to develop and validate a central nervous system (CNS) organoid model of temporal lobe epilepsy (TLE) for drug discovery. The project aims to create a reproducible, 96-well plate format human stem cell-derived neural organoid system that...