Project Grant R41DA047802

Federal Project Grant Award Summary Invizyne Technologies, Inc., a self-certified small disadvantaged business specializing in cell-free biomanufacturing and enzyme engineering, received a $1,034,289 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) effective July 1, 2026 through June 30, 2028. Under this award, Invizyne is developing SIMPLEPATH IIB, a pre-clinical research initiative focused on...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $350,000 to Creighton University to investigate the effects of environmental enrichment on the abuse liability of minor cannabinoids such as delta-8-THC and CBD. The research aims to determine if adolescent exposure to high- or low-novelty environments can alter sensitivity to these cannabis compounds using animal models....

This $465,250 Project Grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a two-year clinical research study examining pregnenolone as a potential treatment for cannabis intoxication. The Johns Hopkins University will conduct a double-blind, placebo-controlled human laboratory study investigating whether pregnenolone, a negative allosteric modulator of the CB1 cannabinoid receptor, can reverse acute cannabis...

Federal Project Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $429,162 Project Grant (CFDA 93.395, Cancer Treatment Research program) effective August 1, 2025 through July 31, 2027 to conduct a prospective feasibility study exploring the neuroprotective potential of cannabidiol (CBD) in preventing oxaliplatin-induced peripheral neuropathy in colorectal cancer patients. The research deliverables include: (1) evaluation of the feasibility and...

This Project Grant awarded by the National Institute of Justice (NIJ), under the CFDA 16.560 National Institute of Justice Research, Evaluation, and Development Project Grants program, will develop and validate advanced analytical methods for the differentiation of hemp and marijuana, including the detection of emerging Δ9-THC positional isomers. The $216,763 award to Sam Houston State University will leverage liquid chromatography-mass spectrometry techniques combined with copper phosphine...

Federal Project Grant Award Summary Oregon Health & Science University received a $429,000 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded July 15, 2025, with a completion date of June 30, 2027. The award funds research to develop innovative photopharmacological tools for investigating tetrahydrocannabinol (THC) signaling mechanisms in brain reward circuits. The primary deliverable is the advancement...

This federal Project Grant award of $396,988.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to optimize non-D9-THC containing cannabis-based treatment approaches for Autism Spectrum Disorder (ASD). The research aims to empirically assess the therapeutic efficacy of cannabidiol (CBD) alone and in combination with common cannabis terpenes on ASD-like...

This $668,110 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund the development and acceptability testing of a technology-based intervention to reduce cannabis misuse among college students. The project aims to refine an existing intervention that provides information on cannabis products, marketing, laws, and risks to increase young adults' cannabis literacy. The research will involve focus groups with...

Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a Project Grant of $385,638 to The Regents of the University of Colorado (University of Colorado-Denver) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2025, with a completion date of August 31, 2028. This research award funds a three-year neurobehavioral investigation titled "Cannabinoid Tolerance Across Neurodevelopment: Disruption of Value-Driven Behavior and Prevention Through...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $3.23 million Project Grant to The Regents of the University of Colorado (University of Colorado-Denver) on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273). This four-year research project, concluding August 31, 2029, will investigate the effects of full-spectrum cannabidiol (CBD) on alcohol consumption and alcohol use disorder (AUD) phenotypes to inform precision medicine approaches. The research...