Project Grant R41DA045398

This $500,000 project grant from the National Science Foundation Division of Electrical, Communications and Cyber Systems Engineering program will fund research into magnetoelectric nanoparticles as multi-field controlled devices for wireless brain stimulation. Led by researchers at the University of Miami, the three-year project aims to experimentally study the feasibility of using magnetoelectric nanoparticles to achieve wireless deep brain stimulation with sub-millimeter spatial resolution in...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...

This federal Cooperative Agreement award of $2,113,446 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a control policy that integrates a novel brain-based biomarker with additional measures to guide long-term Deep Brain Stimulation (DBS) treatment for Treatment Resistant Depression (TRD). The goal is to implement and scale the use of this...

This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $816,604 to The University of Texas M.D. Anderson Cancer Center to conduct research on personalizing repetitive transcranial magnetic stimulation (rTMS) interventions for substance use disorders (SUDs). The research aims to determine the extent to which two neuromarkers - reward reactivity and cognitive control - moderate the effects of...

This Cooperative Agreement award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,983,510 to The Leland Stanford Junior University to conduct a two-phase research study on the use of deep transcranial magnetic stimulation (Deep TMS) to target the neural circuits associated with methamphetamine use disorder. The first phase (UG3) will enroll 30 participants to assess whether the specific Deep TMS protocol can...

This federal Project Grant award of $514,178, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the mechanistic relationship between brain circuit function and negative valence system behaviors in individuals with treatment-resistant depression (TRD). The research will utilize low-intensity focused ultrasound (LIFU) to noninvasively and reversibly modulate deep brain circuits, such as the...

This $9.1 million project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of fast multichannel magnetothermal genetics for neural circuit modulation. The goal is to create a wireless, injectable, and fast-acting neuromodulation technology using magnetic fields to heat genetically-targeted nanoparticles and activate thermoreceptors with sub-second latency. This will allow precise synchronization of neural stimulation...

This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $830,409 to Brigham & Women's Hospital Inc. to develop novel software and computational techniques integrating real-time transcranial magnetic stimulation (TMS) electric-field mapping, electroencephalogram (EEG) source imaging, and subject-specific target localization. The goal is to enhance the accuracy of TMS targeting and dosimetry to...

This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative program (CFDA 93.372), provides $2,048,884 to Baylor College of Medicine to conduct an early feasibility study on using deep brain stimulation (DBS) to treat treatment-resistant bipolar depression (TRBD). The key products and services to be delivered under this award...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $898,025 to the University of Cincinnati to evaluate the use of transcutaneous spinal direct current stimulation (tsDCS) to modulate spinal interoceptive pathways (SIPs) and their role in Major Depressive Disorder (MDD) symptoms. The research aims to assess tsDCS-induced changes in laser-evoked potentials (LEPs) as neural markers of SIPs engagement...