This Project Grant award from the National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training Program (CFDA 93.859), provides $421,250 to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. to develop computational methods for analyzing and interpreting gene regulation in human diseases through the integration of genomic data across hundreds of cell types. The key objectives of this 5-year project are to: 1) develop statistical...
This four-year, $1.388 million project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between New York University and other organizations to discover the principles of active self-organization in the differentiating genome. The research will integrate state-of-the-art live cell experiments with multiscale mathematical and computational models of chromatin dynamics in the cell nucleus. Experiments will...
This $292,727 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports a research project by The Broad Institute, Inc. to discover novel regulators of 3D genome organization. The project aims to leverage large-scale genomic datasets to predict and experimentally validate new trans-acting factors that regulate chromatin interactions and genome architecture. By applying deep neural network models to in silico genetic...
The University of California Irvine will use a $2.83 million project grant from the Department of Health and Human Services' National Institute of General Medical Sciences to decipher the mechanism of long-range gene regulation in vivo. Over a three-year period ending August 2025, UC Irvine researchers will utilize efficient enhancer replacement technology in mice to systematically characterize long-range enhancer activity and identify cis-regulatory sequences critical to this function. A...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
This $890,066 Project Grant award, issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), will support research at the University of Chicago to investigate the genetic and epigenetic mechanisms that regulate long-distance interactions between enhancers and promoters in vertebrate genomes. The research aims to 1) identify the genetic instructions and processes that determine the 3D folding of genomic loci and...
This $240,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) funds a postdoctoral research fellowship to investigate the role of genome organization on de novo gene origination. The research aims to test a new theoretical model explaining the process of new gene evolution, by examining how the genome's structural features influence the birth of genes that arise from non-coding regions. The key components of the research include: 1)...
This National Science Foundation project grant of $1,011,518 supports collaborative research between the University of California, San Diego and the State of California Controller's Office to discover the principles of active self-organization in the differentiating genome. The award period is from July 1, 2022 through June 30, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The project will integrate state-of-the-art live cell experiments with multiscale mathematical...
This $564,510 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will develop computational methods and tools to learn mechanisms in cell differentiation and development from complex, high-dimensional single-cell multi-omics data. The Georgia Tech Research Corporation will receive funding from September 1, 2022 to August 31, 2027 to analyze single-cell RNA sequencing, genome, chromatin accessibility, protein abundance and spatial location data. The...
The National Human Genome Research Institute (NHGRI) awarded a $1,350,896 Project Grant (CFDA 93.172 - Human Genome Research) to the University of California, San Diego to develop novel technology for studying how regulatory DNA sequences control gene transcription. The goal is to create a "multimodal MPRA platform" that can simultaneously measure the effects of regulatory sequence perturbations on chromatin state, protein-DNA interactions, 3D chromatin interactions, and...