The Regents of the University of California, San Francisco (UCSF) received a $709,872 Project Grant award from the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on July 15, 2024. The grant will fund the development and pilot testing of a couple-based intervention targeting perinatal depression and improving adherence to prevention of mother-to-child transmission (PMTCT) of HIV among pregnant women living with HIV in Malawi. The project aims to (1) develop a couple-based intervention using problem-solving therapy and content on couple communication and problem-solving skills, and (2) assess the feasibility and acceptability of the intervention through a pilot randomized controlled trial with 60 pregnant women and their male partners. Outcomes will focus on maternal perinatal depression symptoms, PMTCT adherence, and related factors such as food insecurity and couple communication. This project is part of the NIH's broader efforts to address infectious diseases, improve maternal and child health, and leverage couple-based approaches for mental health treatment in resource-limited settings.
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