The antidote institute- advancing new toxicology investigators in drug abuse and original translational research efforts

Active Project Grant Awarded Last action

Award ID
R25DA058490
Recipient
Awarding agency
Obligated
$1,831,774

Award facts

Assistance listing
93.279 Drug Use and Addiction Research Programs
Completion date 72% complete
Place of performance
Worcester, MA 01655, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
/absract this proposal is responsive to PAR-21-320 with two overarching goals: 1) to provide empiric training in research methodology and hypothesis-driven research, and 2) to train a diverse cadre of clinical medical toxicologists as independent researchers at the intersection of substance use disorder (SUD) and public health. The epidemics of SUD are in sore need of innovation and diversity among researchers. Medical toxicology is a field of medicine dedicated to the evaluation and treatment of poisoned patients, including adverse health effects of drugs and illicit substances. Medical toxicologists have a track record of innovation and public health-relevant research in SUD; however, few pursue careers as independent, federally funded investigators. In response to this GAP in our specialty, we developed in collaboration with the american college of medical toxicology, a hybrid research mentorship program, the antidote (advancing new toxicology investigators in drug abuse and original translational research efforts) institute. The antidote institute provides structured research methodology training and mentorship to medical toxicologists with a long-term goal of developing a pipeline of medical toxicology physician scientists that achieve independent federal funding in SUD research. This R25 proposes to formalize antidote by extending our curriculum for a more rigorous training experience, providing seed funding to accelerate the progress of institute fellows in SUD research, and expanding institute activities to include outreach and multi-generational mentorship. The expanded two-year antidote curriculum will be delivered using a hybrid approach including in-person retreats, virtual group meetings/didactics, and virtual one-on-one meetings. We have assembled a strong multi- disciplinary faculty who are experts in research methodology, innovators in the care of SUD, and master educators. The specific aims of this proposal are: 1) to expand, implement and widely disseminate the antidote institute with a curriculum grounded in participatory learning theory to support the development of toxicologists as clinician scientists: 2) to evaluate the impact of the antidote institute using a validated program evaluation tools: and 3) to facilitate and sustain the development of a diverse investigator pipeline in medical toxicology, through training in mentorship skills, knowledge translation and outreach. The antiodte institute is the first program of its kind to systematically address educational gaps within medical toxicology training around developing hypothesis-driven research investigations. Successful expansion of the program will facilitate methodologically rigorous and clinically informed research on SUD and create a national network of diverse investigators to sustain this momentum. This framework can then be translated outside of the field of medical toxicology to facilitate pipeline development in other clinical specialties.

Transactions

Action Obligated Date
Amendment $314,491
Amendment $314,491
Amendment $299,403
Amendment $299,403
Amendment $301,993
Original award $301,993

Subawards

Subrecipient Amount Awarded
Northwestern University Dr. Bernard Weigel (Principal Investigator, First Author) ● Oversee all aspects of clinical study design, execution, and analysis. ● Lead the development and… $32,400
The Feinstein Institutes For Medical Research Dr. Cyrus E. Kuschner is core faculty of the Northwell Medical Toxicology department alongside a PhD candidate at the Elmezzi Graduate School for Molecular… $32,400
The Washington University Aim: to provide information as to whether or not GLP-1RA treatment causes connectivity changes between the SN and the NAc, areas important in the brain’s reward… $32,400
The Research Foundation For The State University Of New York Eric E. Kaczor, MD, will commit 0.24 calendar months in Years 1-2. As the PI for the project, he will oversee subject recruitment, data collection, and data… $32,400
Ochsner Clinic Foundation Ochsner will mentor one participant in the Advancing New Toxicology Investigators in Drug Abuse and Original Translational Research Efforts (ANTIDOTE) institute… $3,357
Brigham & Womens Hospital Inc. Dr. Chai is an assistant professor of emergency medicine and medical toxicology at Brigham and Women's Hospital. He has collaborated with Dr. Carreiro over… $146,074
American College Of Medical Toxicology, Inc. Paul Wax, MD, will commit 1.2 calendar months in Years 1-3. As Co-investigator, he will work with the PI (Dr. Stephanie Carreiro) on the study design and… $232,199

Quick answers

Who received award R25DA058490?

R25DA058490 was awarded to University Of Massachusetts Medical School by National Institute on Drug Abuse (National Institutes of Health) on May 1, 2023.

How much is award R25DA058490 worth?

$1,831,774 has been obligated on R25DA058490.

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