Project Grant R25AG096206
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $446,096 to the University of Illinois to develop and implement community-based participatory health research with young adults with Down syndrome. The project aims to reflect the perspectives and lived experiences of adults with Down syndrome, including those from underserved and underrepresented communities, to reduce health disparities and...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $372,904 to The University of Texas Health Science Center at San Antonio to advance cross-national research on aging and cognitive function. The 5-year grant, awarded on September 20, 2025, supports an annual program that recruits, trains, and mentors 16 post-graduate participants dedicated to mastering Down syndrome (DS) clinical research. The program offers hands-on DS clinical...
- The Children's Hospital of Philadelphia (CHOP) received a $732,541 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310). The goal of this 24-month grant, awarded on August 7, 2025, is to develop a transdisciplinary training program to foster a new generation of investigators to pursue research in youth and adults with Down syndrome (DS). The PARTNERS program will provide a week-long in-person short course at CHOP, supplemented by...
- This Project Grant award, titled "Investigating Neurosciences, A Summer Program to Ignite Research and Education (INSPIRE)", is funded by the National Institute on Aging (CFDA 93.866 - Aging Research) with $215,998.00 and will be implemented from September 2025 to May 2030. The goal of this program is to create an immersive research education initiative that will attract undergraduate science majors to ultimately increase the number of early-stage investigators pursuing careers in...
- The University of California, Davis received a $250,000 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) to conduct a 3-year longitudinal investigation of expressive communication (EC) development in 180 children with Down syndrome from 18 to 54 months of age. The project will use deep-phenotyping and dense-sampling methods, both in-person and via telehealth monitoring, to enhance understanding of the variability, nature, and...
- This Project Grant award of $234,000 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate how Down syndrome affects the immune system. Specifically, the project will use a novel single-cell sequencing approach to analyze how the extra copy of chromosome 21 in Down syndrome disrupts the normal regulation of genes involved in the interferon immune response. The goal is to...
- The University of Colorado received a $430,375 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) on July 17, 2025. The funding will support research to define the association between Down's syndrome (trisomy 21) and placentation defects. The project aims to identify transcriptional differences in trisomy 21 implantation-stage trophoblasts and assess the role of the NRIP1 gene in trophoblast differentiation. This innovative...
- This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $322,000.00 to Case Western Reserve University to perform the following: Analyze electroencephalographic (EEG) and plasma Alzheimer's disease (AD) biomarker data collected during a previous clinical trial studying the effects of the drug memantine on adolescents and young adults with Down syndrome. The analysis will examine the...
This federal Project Grant award of $866,506 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant supports the Include Clinical Researcher Training (ICRT) program, which plays a crucial role in the INCLUDE project. This new R25 program, responsive to PAR-22-195, recruits, trains, mentors, and provides career advice to cohorts of 16 post-graduate participants dedicated to mastering Down syndrome (DS) clinical research. The program, led by multiple principal investigators, offers annual advanced hands-on DS clinical research lab courses, provides ongoing post-course mentoring, and supports participants in articulating their long-term career trajectories. The overall goal is to address the shortage of laboratories led by DS expert scientists and new clinical trainees with DS expertise. This grant award was made on September 20, 2025 and has an ultimate completion date of August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $866.5k | 9/16/25 |