Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
Ended Project Grant Awarded Last action
- Award ID
- R21TW012384
- Recipient
-
Stellenbosch University UEI C6CHDMTANVS3
- Awarding agency
-
Fogarty International Center
National Institutes of Health, Department of Health and Human Services
- Obligated
- $333,271
Award facts
- Assistance listing
- 93.310 Trans-NIH Research Support
- Completion date
- Originally
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- South Africa
Award details come from USAspending.gov.
Description
- Abstract
- Antiretroviral therapy (art) has dramatically changed the health outcomes of people with HIV (PWH). Newer art regimens with more robust viral suppression may allow complacency creep for imperfect adherence, given the regimen forgiveness for achieving suppressed viral loads despite imperfect adherence. In turn, imperfect adherence may lead to ongoing viral replication below the clinically-relevant suppression threshold, driving inflammation and premature aging. Accumulating data indicate that underlying inflammation strongly contributes to PWH continuing to develop non-communicable diseases (NCD) despite viral suppression, with studies showing a 2-fold increased risk of a significant NCD, HIV-associated stroke, compared to people without HIV. HIV-associated stroke is associated with major mortality, morbidity, and healthcare economic burden. The current investigators found a stroke prevalence of 6.2% in south african PWH with suppressed viral loads compared to people without HIV. PWH were almost 10 years younger, had less traditional cardiovascular risk factors, and were predominantly female, despite being virally suppressed to
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $1 | |
| Amendment | $284 | |
| Amendment | $284 | |
| Amendment | $284 | |
| Amendment | $284 | |
| Amendment | $284 | |
| Amendment | $165,924 | |
| Amendment | -$165,924 | |
| Amendment | $165,925 | |
| Original award | $165,925 |
Show all 11
Quick answers
Who received award R21TW012384?
R21TW012384 was awarded to Stellenbosch University by Fogarty International Center (National Institutes of Health) on August 7, 2023.
How much is award R21TW012384 worth?
$333,271 has been obligated on R21TW012384.
Which agency awarded R21TW012384?
Fogarty International Center (National Institutes of Health) awarded R21TW012384, with funding from Office of the Director (National Institutes of Health).
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