This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $422,125.00 to the University of Miami to investigate the role of the CCL2/CCR2 signaling pathway in regulating HIV-associated ischemic stroke. The key objectives are to: 1) Evaluate the role of astrocyte-derived CCL2 in recruiting pro-inflammatory HIV-infected...
This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $619,511 will fund a study at the University of Miami to investigate the impact of aging on metabolic deficits and immune dysfunction in people living with HIV (PWH). The 5-year study (July 2024 - June 2029) will evaluate the serum metabolic profiles of PWH and how this influences the function, phenotype, and transcriptional profiles of key immune cell types. The research aims to identify senescent and metabolic...
This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This federal Project Grant award for $873,784 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support the development and pilot testing of an intervention called Project Vuselela. The intervention integrates peer navigation and family engagement to improve antiretroviral therapy (ART) adherence and opioid substitution therapy (OST) continuation among people who inject drugs (PWID) in South Africa. The primary goals are to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $100,558 to Stellenbosch University in South Africa to conduct a series of prospective, multimodal cardiovascular research studies. The key objectives are to: 1) investigate the inflammatory pathways associated with heart muscle edema and fibrosis in people living with HIV (PLWH) by measuring and describing an extensive serum...
This $983,672 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research to characterize the in-situ interactions between HIV-infected cells and the central nervous system (CNS) in people living with HIV (PWH), with a focus on understanding the impact of methamphetamine use. The project aims to develop and implement innovative spatial multi-omic assays to analyze the localization, distribution, and activity of...
This $2,812,966 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to study the impact of drug abuse-mediated inflammatory changes on the development of anti-CD4 autoantibodies and impaired immune reconstitution in people living with HIV (PWH) on antiretroviral therapy. The research, led by the Medical University of South Carolina and involving sub-awardee Columbia University, aims to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a 5-year, $1,550,462 study to investigate the impact of Alzheimer's disease (AD) risk genes on brain function in HIV-positive older Black/African American adults. The multidisciplinary study will enroll 120 HIV-positive participants (60 with and 60 without the APOE E4 gene variant) and 80 demographically matched controls to assess cognitive function, brain imaging, and biomarkers related to...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,738,976.00 to Wake Forest University Health Sciences to investigate the neuroimmune mechanisms linking chronic psychosocial stress, stimulant use, and depression in people living with HIV (PWH). The key objectives are to: 1) examine the causal relationship between a positive affect intervention (ARTEMIS) and improvements in neural functioning in...
This $494,632 Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund the development of a secure data platform to enable collaborative research on the prognosis and treatment of people with HIV in North America and Europe. The key products and services to be delivered under this 5-year project include: Enhancing understanding of cause-specific mortality and...