Project Grant R21NS147992
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Roskamp Institute, Inc. a Project Grant of $468,875 under the Aging Research program (CFDA 93.866) effective January 1, 2026, through December 31, 2027. This award supports biomedical research investigating the effect of delayed microglial-specific peroxisome proliferator-activated receptor gamma (PPARG) activation on ameliorating chronic neuroinflammation and cognitive dysfunction following repetitive mild...
- Federal Project Grant Award Summary Enrectec LLC received a $950,028 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on September 22, 2025, with completion scheduled for March 22, 2027. The award supports Phase I feasibility studies for the development of a novel neurotrophic therapeutic molecule designed to address cognitive deficits in Alzheimer's disease. The project deliverables include bioreactor scaleup testing for recombinant...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of South Florida $3.297 million under the Aging Research program (CFDA 93.866) for a four-year project period (September 1, 2025 – August 31, 2029) to develop novel peptidomimetic biomaterials that inhibit amyloid-beta (Aβ42) aggregation in Alzheimer's disease. The research deliverables include the rational design and characterization of structurally related analogues to a lead compound that stabilizes Aβ...
- This federal Project Grant award for $327,194 was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to The Roskamp Institute, Inc., a biotechnology research organization based in Sarasota, Florida. The purpose of this 3-year award, with a performance period from September 1, 2024 to August 31, 2027, is to conduct research on delineating the therapeutic effect of PTEN inhibition for mitigating chronic microglia activation and the...
- Federal Project Grant Award Summary Advantage Therapeutics, Inc. received a $3.75 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on September 20, 2025, with completion targeted for May 31, 2027. The award funds Investigational New Drug (IND)-enabling studies for a disease-modifying small-molecule therapeutic candidate for Alzheimer's disease. The research will advance preclinical development and regulatory preparation of...
- Federal Grant Award Summary The Buck Institute for Research on Aging received a $809,486 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion scheduled for January 31, 2031. This award supports biomedical research investigating the role of oxidation resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's Disease and Related Dementias (ADRD). The research deliverables include...
- Federal Grant Award Summary Alphamemory, LLC received a Phase I Small Business Technology Transfer (STTR) award of $504,248 from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop novel therapeutic compounds targeting Alzheimer's disease. The award, effective September 20, 2025, through September 19, 2027, funds drug discovery research focused on selectively reducing amyloid production through compounds that target the transmembrane domain of the amyloid...
- The U.S. Defense Health Agency awarded a $817,200 Project Grant under the Military Medical Research and Development program (CFDA 12.420) to The Roskamp Institute, Inc. in Sarasota, Florida. The grant, awarded on September 1, 2024, will support a 3-year research project titled "Targeting APOE Bioenergetics for Reducing the Risk of Neurodegeneration After Chronic Traumatic Brain Injury." The research aims to investigate mitochondrial bioenergetics, tau protein pathology,...
- Federal Project Grant Award Summary The Defense Health Agency (DHA) awarded Scripps Research Institute a $769,972 project grant effective August 1, 2026, through July 31, 2029, under the Military Medical Research and Development program (CFDA 12.420). This award supports hypothesis-driven biomedical research investigating redox-mediated neurotoxicity associated with military-related toxic exposure in Parkinson's disease. The research will be conducted at Scripps Research Institute's La Jolla,...
- Federal Project Grant Award Summary 3P Biotechnologies, Inc. received a $506,434 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on September 15, 2025, with a completion date of August 31, 2026. This Phase I project focuses on developing a targeted exosomal delivery system for curcuminoids—specifically curcumin (CUR) and bisdemethoxycurcumin (BDMC)—to treat Alzheimer's disease and mitigate neuroinflammatory disease progression. The...
The Roskamp Institute, Inc. received a $468,875 Project Grant award dated May 20, 2026, under the Trans-NIH Research Support program (CFDA 93.310) from the National Institute on Aging, Office of the Director. The award funds preclinical development research evaluating oleoylethanolamide (OEA) as a medical countermeasure for chronic long-term neurotoxicity following organophosphate exposure. The research will examine OEA's pharmacokinetics and pharmacodynamics in animal models, identify optimal formulations and dosing regimens that achieve gut target engagement, and assess the compound's therapeutic potential for reducing chronic sequelae including fatigue, anxiety, cognitive impairment, and autonomic dysregulation associated with organophosphate poisoning. The award period extends through April 30, 2028, with performance conducted at the institute's facility in Sarasota, Florida. This grant supports translational research addressing a significant public health gap, as currently no FDA-approved medical countermeasures exist for managing chronic neuroinflammatory complications in survivors of acute organophosphate exposure from pesticides or nerve agents. The research leverages OEA's mechanism of action through the gut-vagal-brainstem axis and builds upon the institute's preliminary clinical findings in Gulf War Illness, a chronic multisymptom illness with overlapping symptoms observed in survivors of chemical weapons attacks. The project aligns with the Trans-NIH Research Support program's emphasis on advancing innovative therapeutic approaches with potential for significant public health impact across military, veteran, and civilian populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $468.9k | 5/22/26 |