Project Grant R21HD123328
- The National Institute of General Medical Sciences awarded The Mount Desert Island Biological Laboratory $422,500 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms of limb and tail regeneration in axolotls as a foundation for developing strategies for scarless tissue regeneration in humans. The research examines why axolotls regenerate limbs and tails without scarring through blastema formation, whereas mammals form...
- The National Institute of Child Health and Human Development awarded University of Massachusetts Boston $515,382 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on cellular regulation of pattern in regenerating limb tissue. The research examines how anterior and posterior limb cells direct regeneration of precisely the missing structures in Mexican axolotl limbs, using spatial transcriptomics and in vivo regenerative...
- Wake Forest University received a $390,101 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through July 31, 2027. The award funds research to interrogate the molecular mechanisms of limb regeneration in the Mexican axolotl salamander (Ambystoma mexicanum) using a viral molecular toolbox. The primary deliverables include the development...
- The National Institute of General Medical Sciences awarded Louisiana State University $375,000 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund a five-year comparative study identifying shared molecular and cellular mechanisms of limb and fin regeneration across regenerative and non-regenerative vertebrate species. The research employs a multiscale comparative approach using the axolotl (Mexican salamander), Senegal bichir, African lungfish,...
- The National Institute of General Medical Sciences awarded the University of Washington $287,219 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate metabolic reprogramming in vertebrate appendage regeneration. The research examines how animals mobilize biomolecules—nucleotides, proteins, and lipids—to regrow lost appendages, using the frog Xenopus tropicalis as a model organism. The principal investigator's central hypothesis is that...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $393,008 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the regulation of cell fate specification during the regeneration of complex sensory organs. The funded research uses the freshwater apple snail (Pomacea canaliculata) as a model organism to uncover molecular mechanisms driving...
- The National Institute of Child Health and Human Development awarded The Morgridge Institute For Research, Inc., $131,832 on August 21, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on appendage regeneration signaling and transcriptional programs. The award funds investigation into how signaling dynamics, transcriptional output, and physiological cues control regenerative growth in zebrafish dermal appendages, using live imaging,...
- The National Institute of General Medical Sciences awarded The Marine Biological Laboratory $471,625 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate Wnt pathway activation and cell signaling using sea star oocytes as a model system. The research examines how Dishevelled (DVL), a protein essential to Wnt pathway integration, assembles into cytoplasmic structures upon hormonal stimulation of oocytes, and investigates oocyte-derived...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded $153,560 to the University of California, Santa Barbara on November 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing). The recipient will conduct physiological, molecular, and bioinformatic experiments to determine the role of circadian rhythms in modulating wound healing and whole-body regeneration, with focus on identifying the...
- The National Science Foundation Division of Mathematical Sciences awarded Northeastern University $674,161 on August 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop a multiscale computational framework for understanding tissue regeneration in organisms such as axolotls. The five-year project runs through July 31, 2031, with work performed in Boston, Massachusetts. The research integrates continuum mechanics, stochastic agent-based modeling, neural network...
The National Institute of Child Health and Human Development awarded The Marine Biological Laboratory $431,112 on September 1, 2026, under the Child Health and Human Development Extramular Research program (CFDA 93.865) to investigate the role of neuropeptides in appendage regeneration. The research seeks to understand why salamanders and axolotls regenerate lost limbs, jaws, tails, and other tissues while humans retain only limited regenerative capacity. The work addresses therapeutic applications ranging from scarless wound healing to treatments for degenerative diseases and potential human limb regeneration. The project focuses on long-distance signaling mechanisms—specifically neuropeptide-mediated signals traveling from the spinal cord and brain to the injury site—that instruct cells to migrate, divide, and form the blastema that drives regenerative growth. The award is a Project Grant, the assistance type category for NIH peer-reviewed extramural research. Performance occurs at The Marine Biological Laboratory in Woods Hole, Falmouth, Massachusetts, with a period of performance from September 1, 2026, through August 31, 2028. The Marine Biological Laboratory is a nonprofit research institution that delivers fundamental biological research, advanced research training, and specialized laboratory facilities including live research organisms and microscopy infrastructure to federal science agencies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.1k | 8/20/26 |