Project Grant R21HD119634
- The National Institute of Child Health and Human Development awarded $990,342 to the Regents of the University of Michigan on August 13, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on intergenerational programming of neurodevelopmental disorders. The research constructs a multigenerational cohort of more than 1.4 million grandmaternal-parental-offspring triads using linked nationwide Swedish registries to examine associations...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded the University of Miami $664,101 on June 1, 2026, to investigate the impact of disease-associated mutations in the Polycomb system, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research focuses on how missense mutations in genes encoding Polycomb Repressive Complex 1 components—specifically RNF2 (RING1B)—impair human development and contribute to intellectual disabilities and...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $635,308 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to investigate the long-term epigenetic consequences of DNA damage during embryonic development. The research examines how double-strand DNA breaks during gastrulation and organogenesis trigger genome integrity pathways that establish long-term silencing...
- The National Institute of Child Health and Human Development awarded East Carolina University $249,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate calcium-mediated mechanisms of metabolic and epigenetic changes at fertilization in mammals. The research uses mouse models to determine how abnormal calcium dynamics at fertilization impact embryonic epigenetic reprogramming and offspring development. The work addresses...
- The National Institute of Child Health and Human Development awarded The Trustees of Princeton University $315,664 on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how amniotic fluid pressure and composition regulate branching morphogenesis across embryonic organs. The research tests the hypothesis that amniotic fluid couples the rate of branching morphogenesis in organs throughout the embryo, with particular focus on...
- The National Institute of Child Health and Human Development awarded Yale University $132,022 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of histone H4 acetylation in mammalian embryogenesis and maternal aging. The research examines how epigenetic modifications, specifically H4K12ac (histone H4 lysine 12 acetylation), direct cellular transitions during early embryonic development and how dysregulation of these...
- The National Institute of Child Health and Human Development awarded Duke University $581,258 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transposable elements as mechano-response enhancer elements regulating human embryonic stem cell fate. The research examines how mechanical forces regulate transposable element sequences that control gene expression and pluripotent stem cell differentiation. The project tests three...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
- The National Institute of Child Health and Human Development (NICHD) awarded a $161,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Research Foundation for the State University of New York (RF SUNY). The grant, awarded on July 23, 2024, will support research to identify the hepatic epigenomic adaptations to excessive early-life cholesterol exposure due to maternal hypercholesterolemia, and evaluate the efficacy of maternal...
The National Institute of Child Health and Human Development awarded Van Andel Research Institute $528,000 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how gene-environment interactions affect developmental reprogramming through maternal metabolic state and offspring health outcomes. The project examines mechanistic links between maternal metabolism and early embryonic development by studying interactions between SRCAP haploinsufficiency and maternal obesity in Drosophila and mouse models. The research uses low input epigenomics and single-embryo transcriptomics to identify molecular signatures during early developmental stages. Two specific aims establish the mechanistic basis for SRCAP × maternal obesity interactions in Drosophila and identify embryonic changes triggered by these interactions in mice. The preliminary hypothesis holds that maternal obesity exacerbates effects of SRCAP haploinsufficiency, thereby altering early neuronal development; human relevance centers on SRCAP mutations linked to floating-harbor syndrome and autism spectrum disorder. The period of performance runs from August 1, 2026, through July 31, 2028. Work is performed in Wyoming, Michigan. This is a Project Grant, the standard NIH assistance type for investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $528.0k | 7/30/26 |