Project Grant R21HD118636
- The National Institute of Child Health and Human Development awarded Yale University $1.396 million on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging. The award funds research using mouse oocytes to analyze how centromere proteins (including CENP-A and CENP-C), centromeric DNA composition, and microtubule-associated proteins interact to...
- The National Institute of General Medical Sciences awarded Oklahoma Medical Research Foundation $468,875 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the role of SWI/SNF chromatin remodeling complexes in germ line transcription and nuclear organization during meiosis. The funded research addresses errors in homologous chromosome segregation during meiosis, which are the leading cause of birth defects and spontaneous pregnancy...
- The National Institute of Child Health and Human Development awarded Yale University $100,228 on December 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to define the function of tubulin post-translational modifications in female meiosis. The research investigates microtubule organization and chromosome segregation mechanisms in oocytes to probe the molecular origins of egg aneuploidy. The recipient will use mouse oocytes as a model of mammalian...
- The National Institute of Child Health and Human Development awarded The Regents of The University of Colorado (University of Colorado-Denver) $584,626 on July 8, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to define mechanisms regulating functional regionalization of the mammalian ovary during fetal and perinatal development. Using three-dimensional imaging, computational analyses, and single-cell-scale spatial transcriptomics, the research...
- The National Institute of Child Health and Human Development awarded Cornell University $667,092 on August 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on MUTS GAMMA as a driver of crossover pathway choice in prophase I of mammalian meiosis. The research investigates how DNA double-strand breaks formed during meiosis are repaired as either crossovers or non-crossovers, focusing on the role of the MUTS GAMMA heterodimer (MSH4...
- The National Institute of Child Health and Human Development awarded Trustees of Dartmouth College $450,250 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how three RNA-binding proteins—PATL2, PUM1, and PUM2—regulate translational control during oocyte meiosis and early embryogenesis in a mouse model. The research uses cutting-edge technologies to define the unique and shared mRNA targets of these proteins and determine...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded the University of Pennsylvania $100,228 on January 1, 2027, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate long-lived cardiac myosins as regulators of oocyte cytoskeletal integrity and reproductive lifespan. The research examines how exceptionally long-lived proteins—specifically A- and B-cardiac myosin heavy chain proteins (MHC-A/-B)—maintain oocyte cytoskeletal...
- The National Institute of Child Health and Human Development awarded the University of Rochester $149,190 on February 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the molecular mechanisms of sperm dysfunction induced by meiotic drive. The project combines gene editing, genetic, and cytological approaches to study segregation distorter (SD), a sperm-killing male meiotic driver found in natural populations of Drosophila...
- The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types,...
The National Institute of Child Health and Human Development awarded Oklahoma Medical Research Foundation $468,875 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate homologous chromosome dynamics in mouse oocytes. The research addresses aneuploidy, which occurs in 10 to 30 percent of human gametes and typically results from chromosome segregation errors during meiosis, leading to pregnancy loss or genetic disorders such as Down's Syndrome. The project develops a fluorescence reporter-operator system based on the lac operator-lac repressor paradigm to enable protein targeting to specific genomic regions and elucidate mechanisms regulating chromosome segregation during female meiosis. Aim 1 employs the system to study telomere-led rapid chromosome motions in developing mouse oocytes at prophase I, testing the hypothesis that dynein and/or kinesin walking on microtubules generates primary forces for these motions, transmitted to telomeres through the nuclear membrane by the LINC complex. The research uses immunocytochemistry in whole-mounted ovaries, mutant mice, and small molecule inhibitors to reconstruct the machinery supporting and regulating these motions. Aim 2 examines homologous chromosome pairing in real time using four-dimensional fluorescence imaging of tagged chromosomal loci at high spatiotemporal resolution in intact mouse ovaries to test existing alternative pairing models. Performance occurs at Oklahoma City, Oklahoma. The award period runs from August 1, 2026, through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $468.9k | 7/28/26 |