The federal Project Grant award R21EY037083, for $237,996.00, was granted by the National Eye Institute (NEI) under its Vision Research program (CFDA 93.867). The project aims to develop an innovative wide-field, high-resolution imaging system capable of in-vivo visualization of fine corneal structures and cellular-level detail. This system would utilize speckle illumination holographic imaging with polarization and phase sensitivity to overcome limitations of current corneal imaging techniques, such as small field-of-view and physical contact requirements. After optimizing the system, the research team plans to conduct proof-of-concept validation in healthy human volunteers. The proposed imaging approach could significantly impact the study, prevention, diagnosis, treatment, and monitoring of various corneal diseases, with potential benefits extending beyond ophthalmology. The project will be carried out by the Regents of the University of Colorado, a public research institution, over a 2-year period from February 2025 to January 2027.
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