This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $217,449 to the City of Philadelphia Trustee under the Will of James Wills, doing business as The Wills Eye Health System, to develop and evaluate novel subsampling and analysis methods for big data from electronic medical records (EMRs), particularly the Intelligent Research in Sight (IRIS) registry.
The key objectives are to: 1) derive optimal subsampling probabilities for rare and non-rare events data with categorical and numerical covariates; 2) design an effect balancing approach to better include underrepresented subgroups and prevent health disparities; and 3) develop optimal sampling strategies to adjust for selection bias in EMR studies. The outcome will be user-friendly software packages on optimal subsampling for medical research practitioners. This 2-year project, starting September 2024, aims to address critical challenges in leveraging large EMR datasets to conduct valid and efficient epidemiological studies in ophthalmology and other medical domains.
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