Project Grant R21DA065109
- Federal Project Grant Award Summary Meharry Medical College received a $400,125 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded March 15, 2026, with a completion date of February 29, 2028. The grant funds research investigating how persistent microglial HIV reservoirs and neuronal mitochondrial dysfunction contribute to accelerated neurocognitive aging in African Americans with nicotine addiction despite viral...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $2.352 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct neurogenomic research on HIV-infected brains exposed to opioids and other substances. The award, dated February 15, 2026, with completion targeted for January 31, 2030, supports two primary research objectives. First, the project will validate single-cell genomic...
- Federal Grant Award Summary The Scripps Research Institute received a $608,652 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. This award supports a data mining and functional validation initiative focused on the SCORCH (Substance use, Comorbidity, and Opportunities for Recovery and Cognitive Health) datasets. The project will conduct comparative analysis of cell...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Miami's Office of Research Administration at the School of Medicine a $164,190 Project Grant on August 19, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The research project, titled "Dopamine Dysregulation and Oxidative Stress in HIV and Methamphetamine Induced Cognitive Impairment," addresses the overlapping public health epidemics of substance use disorder and...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) under its Drug Use and Addiction Research Programs (CFDA 93.279) awarded $1,387,755 to the University of California, San Diego, effective March 1, 2026, through December 31, 2030. This project grant supports research investigating mitochondrial oxidative phosphorylation dysfunction in the context of HIV-associated neurocognitive disorders (HAND) and opioid use disorder (OUD), with a specific focus on fentanyl...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Maryland, Baltimore a $685,937 Project Grant on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the impact of opioid use disorder (OUD) on mitochondrial dysfunction among antiretroviral therapy (ART)-receiving aging people with HIV (PWH). The research addresses a critical knowledge gap regarding the synergistic effects of long-term ART exposure...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $344,214 Project Grant effective June 23, 2025, through December 31, 2027, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research project investigates the combined role of nicotine and the NLRP3 inflammasome in HIV-1-associated central nervous system (CNS) inflammation, with the objective of elucidating mechanisms underlying neuroinflammation and...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA), under its Drug Use and Addiction Research Programs (CFDA 93.279), awarded $109,652 to the University of Miami's Office of Research Administration on August 19, 2026, for an implementation research study examining telehealth delivery models for HIV and substance use disorder (SUD) care among people who inject drugs (PWID). This one-year project, scheduled for completion by August 18, 2027, will produce research...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded J. David Gladstone Institutes a $1,343,271 Project Grant (CFDA 93.279, Drug Use and Addiction Research Programs) effective May 15, 2025, through March 31, 2030, to develop targeted small molecule recruitment strategies for suppressing the HIV transcriptionally active reservoir in individuals with substance use disorder (SUD). The research addresses a critical gap in antiretroviral therapy (ART), which fails to target latent...
- Project Grant Summary Massachusetts Institute of Technology received a $1.65 million project grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded on July 15, 2025, with an anticipated completion date of March 31, 2030. The project, titled "Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV," delivers advanced computational research analyzing genetic and molecular mechanisms...
Middle Tennessee Research Institute received $408,234 in project grant funding from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period April 1, 2026 through March 31, 2028. The project aims to characterize the role of mitochondrial deoxyribonucleic acid (DNA) genetic variants and endophenotypes in substance use disorders (SUD), neurologic diseases, and epigenetic aging among veterans with and without human immunodeficiency virus (HIV). The research team will utilize data from the Million Veteran Program to investigate the complex interactions between HIV infection, SUD, aging, and mitochondrial dysfunction in explaining neuropathogenesis at a population level. The deliverables include analysis of mitochondrial genetic and endophenotype measures—including mitochondrial DNA copy number, heteroplasmy, and genetic pathogenicity scores—to improve understanding of relationships between SUD, HIV infection, and neurological outcomes. As a research services provider, Middle Tennessee Research Institute will support the project through data management, IT infrastructure, and data preparation activities, leveraging the team's extensive expertise in phenotypic characterization, mitochondrial science, and epigenetic analytics. The research directly addresses NIDA priorities in understanding comorbid conditions involving substance use and HIV/AIDS while contributing to prevention and treatment knowledge for these interconnected health challenges among the veteran population.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.2k | 3/30/26 |