Project Grant R21DA064859
- Federal Grant Award Summary Meharry Medical College received a $400,125 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 17, 2025, through May 31, 2027. The award funds research investigating a novel mechanism by which HIV-1 (Human Immunodeficiency Virus-1) evades the antiviral function of APOBEC3G (A3G), a cellular restriction factor that normally inhibits viral...
- Federal Project Grant Award Summary The University of Miami, through its Office of Research Administration within the School of Medicine, received a Project Grant award of $109,076.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 19, 2026. The award supports research investigating the mechanisms underlying cognitive impairment and neuropsychiatric disorders resulting from the combined effects of HIV infection and...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $685,937 Project Grant to the University of Maryland, Baltimore, effective March 15, 2026, through December 31, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative investigates the impact of opioid use disorder (OUD) on mitochondrial dysfunction in antiretroviral therapy (ART)-receiving aging people with HIV (PWH). The research addresses a critical gap in understanding...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a Project Grant (R21) totaling $439,180 under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period September 1, 2025 through August 31, 2027. This high-risk/reward research initiative investigates dopaminergic neuronal-glial interactions in the striatum to advance understanding of cognitive dysfunction and chronic pain experienced by people living with HIV (PLWH)...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Feinstein Institutes For Medical Research a $616,372 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning July 15, 2025, with a completion date of March 31, 2030. This award supports research investigating transposable element (TE) expression and regulation in the context of HIV-1 infection and cannabinoid exposure at the single-cell and nuclei level. The research leverages a...
- Federal Grant Award Summary The University of California, San Diego received a $1.39 million Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mitochondrial dysfunction as a therapeutic target in HIV-associated neurocognitive disorders and opioid use disorder. The award, obligated on March 1, 2026 with a completion date of December 31, 2030, funds research examining dysregulated oxidative...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $245,562 under the Drug Use and Addiction Research Programs (CFDA 93.279) effective June 23, 2025, with completion targeted for December 31, 2027. This research project investigates the combined effects of nicotine and NLRP3 inflammasome activation on human immunodeficiency virus (HIV)-1-associated central nervous system (CNS) inflammation. The...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of California, San Diego a $3.73 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning April 15, 2025, with a completion date of January 31, 2030. This research initiative investigates the mechanistic intersection of human immunodeficiency virus (HIV) and opioid use on inflammasome-mediated neuroinflammation and neurotoxicity in the central nervous system...
- Federal Grant Award Summary Icahn School of Medicine at Mount Sinai received a $2.352 million Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct neurogenomic research on HIV-exposed brains in the context of opioid and substance use disorder comorbidity. The award, effective February 15, 2026, through January 31, 2030, will deliver two primary research products: (1) single-molecule functional validation of...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $804,728 to the Regents of the University of California at Riverside under the Drug Use and Addiction Research Programs (CFDA 93.279) to support a five-year research project spanning June 1, 2025 through April 30, 2030. This Project Grant will fund research investigating the interaction between methamphetamine use and human immunodeficiency virus (HIV) persistence, specifically examining the role of the...
Meharry Medical College received a $400,125 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) effective March 15, 2026, through February 29, 2028. The award supports research investigating the contribution of neuronal mitochondrial dysfunction and microglial HIV (Human Immunodeficiency Virus) reservoirs to neurocognitive aging in African Americans with nicotine addiction and viral suppression. The research addresses how persistent microglial HIV reservoirs, exacerbated by nicotine exposure, disrupt neuronal mitochondria and accelerate cognitive decline despite effective antiretroviral therapy, ultimately contributing to HIV-associated neurocognitive disorders (HAND). The funded research delivers two primary investigative products: quantification of mitochondrial DNA (mtDNA) in neuron-derived extracellular vesicles (NEVs) from blood plasma to assess neuronal mitochondrial dysfunction and its link to neurocognitive impairment, and measurement of HIV RNA in microglia-derived extracellular vesicles (MEVs) from blood plasma to assess microglial reservoir activity and its contribution to neurocognitive aging. These research activities are designed to generate new knowledge and therapeutic approaches targeting health disparities in substance use and HIV/AIDS among underserved African American populations, aligning with the Drug Use and Addiction Research Programs' mission to support translational research addressing comorbid conditions and social determinants affecting individuals with substance use disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.1k | 3/10/26 |