Project Grant R21DA037556

The National Institute on Drug Abuse (NIDA) awarded the University of Texas Health Science Center at Houston $2,085,384 on June 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a pilot mechanistic study investigating semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), as a potential treatment for cocaine use disorder (CUD). This R01 Stage IIA project, which will conclude February 28, 2029, will generate proof-of-concept evidence demonstrating...

This five-year, $573,638 project grant from the National Institute on Drug Abuse, part of the Department of Health and Human Services, supports research into the neural mechanisms of individual differences in cocaine avoidance. Funded under the Drug Abuse and Addiction Research Programs (CFDA 93.279), the grant to the Medical University of South Carolina will examine cellular mechanisms by which serotonin and glutamate receptors in the rostromedial tegmental nucleus drive aversive conditioning...

The National Institute on Drug Abuse (NIDA) awarded $795,090 to the University of Texas Medical Branch at Galveston under the Drug Use and Addiction Research Programs (CFDA 93.279) Project Grant mechanism, effective September 1, 2025, through May 31, 2030. This research initiative focuses on the discovery and development of G protein-coupled receptor 52 (GPR52) ligand probes as novel therapeutic targets for cocaine use disorder (CUD). The project employs an informatics-driven approach to...

Iontx Inc. received a $400,000 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop novel pharmacological treatments for cocaine use disorder (CUD). The award, issued on May 15, 2025, with a completion date of April 30, 2026, supports the optimization and preclinical evaluation of a first-in-class small-molecule modulator targeting the FGF13 (fibroblast growth factor 13) and NAV1.6 (voltage-gated sodium...

The University of Pennsylvania received a $527,837 Project Grant award from the National Institute on Drug Abuse, part of the Department of Health and Human Services, to study altered midbrain GABAergic circuitry and its role in driving greater cocaine self-administration. Specifically, the researchers will characterize the functional state of midbrain GABAergic circuitry and the disposition of the KCC2 potassium-chloride cotransporter during cocaine self-administration, extinction, and...

Federal Project Grant Award Summary Louisiana State University Health Sciences Center New Orleans received a $225,000 Project Grant award from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a preclinical rat model of concurrent cocaine base vapor inhalation and alcohol use. The award, effective September 1, 2025 through July 31, 2027, supports research that establishes a novel inhalation delivery system for...

This federal Project Grant award of $234,000.00 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research at Oregon Health & Science University to investigate rapid protein translation in nucleus accumbens neurons in response to a cocaine-associated cue. The goal is to understand the mechanisms underlying cue-induced cocaine craving, a core feature of substance use disorder. The research will...

Federal Grant Award Summary Wake Forest University Health Sciences received a $758,218 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. The project investigates nociceptin/orphanin FQ peptide (NOP) receptors as potential pharmaceutical targets for treating cocaine use disorder (CUD), addressing a significant public health gap given the absence of FDA-approved...

Federal Grant Award Summary Wake Forest University Health Sciences received a $474,347 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning August 15, 2025, with completion scheduled for April 30, 2030. The award supports research investigating the impact of nicotine and alcohol co-use on cocaine abuse potential using cynomolgus monkey models. The research directly addresses a critical public health gap, as...

Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $3.24 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 1, 2025, with completion targeted for February 28, 2030. This grant supports a double-blind randomized clinical trial investigating cognitively-enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) combined with...