Project Grant R21AG087044
Award Date
12/1/24
Completion Date
11/30/26
Dollars Obligated
$356K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94158, USA
Similar Awards
This $574,474 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports the development and preclinical testing of self-adjuvanting peptide nanofiber (PNF) vaccines targeting amyloid-beta (Aβ) and tau proteins for the treatment of Alzheimer's disease (AD) and frontotemporal dementia (FTD). The Washington University in St. Louis, the prime awardee, will lead this effort in collaboration with the University of Texas Medical Branch at Galveston as a...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $444,890 to The Regents of the University of California, San Francisco (UCSF) to support research exploring the mechanisms of protein transmission in Alzheimer's disease (AD) and Lewy body dementia (LBD). The project aims to identify key genes that mediate the selective spreading of different protein conformers, such as pathological tau in AD and alpha-synuclein in LBD, across neuronal...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,342,415 to the University of California, Irvine (UC Irvine) to investigate the adverse cerebrovascular responses to antibodies targeting beta-amyloid, a key component associated with Alzheimer's disease. The research aims to:
Elucidate the temporal sequence and vascular aging factors that contribute to adverse central nervous system blood vessel responses to passive...
This $794,341 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. Key objectives include using experimental mouse models, molecular characterization of endogenous retroviruses, and human induced pluripotent stem cell models to study how viral and bacterial infections can initiate...
This Project Grant award, valued at $109,595.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award supports comprehensive microscopic studies to characterize a novel nonhuman primate model of Alzheimer's disease pathology at the University of California, Davis.
The research aims to:
Determine the regional and laminar patterns of tau-based neuropathology and neuronal loss within the entorhinal cortex, hippocampus, and...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD).
The project aims to develop new...
This $4,276,054 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF). The grant will fund a 3-year research project focused on mathematically modeling the selective vulnerability of genes, cells, and neural networks in mouse tauopathy models of Alzheimer's disease (AD).
The proposed research aims to quantitatively test and validate hypotheses...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), aims to investigate the role of peripheral, aged CD8+ T cells in driving age-related cognitive decline. The $133,396 award to the Regents of the University of California, San Francisco (UCSF) will fund research to determine the molecular and cellular changes in the aged hippocampus elicited by aged CD8+ T cells, as well as the specific effects of the CD8+ T cell-derived...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $119,071 to The Regents of the University of California, San Francisco (UCSF) to develop innovative computational tools to rebuild Tau amyloid epitopes observed in Frontotemporal Dementia (FTD) patients. The goal is to use these designed protein structures to investigate how Tau amyloid epitopes interact with their biochemical microenvironment and elucidate their role in Tau-mediated...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to generate a comprehensive atlas of neurovascular protein lifetimes in health, aging, and a tauopathy-based model of Alzheimer's disease. The $437,875 award provides funding to researchers at the University of California, San Diego to employ stable isotope labeling in mammals (SILAM) and mass spectrometry-based proteomics to quantify changes in neurovascular protein lifetimes during...