Project Grant R16HD122676
- The National Institute of Child Health and Human Development (NICHD) of the Department of Health and Human Services awarded North Carolina State University $673,394 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to decode epigenetic networks that orchestrate endometrial function. The project addresses molecular mechanisms underlying uterine dysfunction in recurrent implantation failure and recurrent pregnancy loss, which remain major...
- The National Institute of Child Health and Human Development awarded The Trustees of Columbia University in the City of New York $444,824 on August 20, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to engineer human pluripotent stem cell (HPSC)-derived endometrial organoids for modeling regeneration and disease mechanisms. The project will develop an innovative platform that recapitulates physiological interactions and developmental trajectories...
- The National Institute of Child Health and Human Development awarded the University of Missouri System $500,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate molecular mechanisms underlying endometriosis-associated infertility. The award is a Project Grant (R56HD122660). The research addresses the role of the transcription factor FOXA2 in endometriosis development and related infertility. The investigative team will...
- The National Institute of Child Health and Human Development awarded Oregon State University $444,498 on August 18, 2026, to develop nanoparticle-mediated chemodynamic therapy for endometriosis under the Child Health and Human Development Extramural Research program (CFDA 93.865, Project Grant R01HD121601). Endometriosis affects approximately 176 million women worldwide, causing severe pelvic pain and infertility with no cure. Current clinical therapies cause infertility, and surgical lesion...
- The National Institute of Child Health and Human Development awarded Trustees of Tufts College $351,945 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate inflammation resolution mechanisms in endometrial health and disease. The research dissects how specialized pro-resolving mediators, a class of lipid-derived molecules that orchestrate inflammation resolution, operate in the human endometrium across the menstrual cycle. The...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded the University of Kansas Medical Center Research Institute, Inc. $662,769 on September 1, 2026, to define the role of RPLP1 and RGS1 in endometriosis and adenomyosis pathophysiology under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project investigates cellular mechanisms underlying two common gynecological diseases in women of reproductive age. The recipient will characterize RPLP1 and...
- The National Institute of Child Health and Human Development awarded Michigan State University $3.548 million on September 12, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct transcriptomic analyses of early endometriotic lesion development. The recipient, doing business as Henry Ford Health+Michigan State University Health Sciences, will integrate single-cell, spatial, and bulk transcriptomics analyses of peritoneal endometriotic lesions...
- The National Institute of Child Health and Human Development awarded the University of Cincinnati Sponsored Research Services Division $696,598 on July 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of environmental phthalates in endometriosis development. The research uses a mouse model of endometriosis to examine how high and low molecular weight phthalates—bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate...
- The National Institute of Child Health and Human Development awarded The Regents of the University of Colorado (University of Colorado-Denver) $124,125 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of the Hedgehog signaling pathway—specifically GLI2—in endometrial remodeling and placental development. The project uses a mouse model with conditionally deleted uterine GLI2 to examine how the Hedgehog signaling...
The National Institute of Child Health and Human Development awarded Marshall University Research Corporation $147,500 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate epigenetic regulation of CXCR4 in endometriosis. The research examines aberrant promoter methylation dynamics of CXCR4, a master regulator involved in endometrial cell migration, stem cell trafficking, and lesion formation in endometriosis. The project aims to identify CXCR4 promoter methylation as a novel biomarker for earlier diagnosis and non-hormonal therapeutic target for endometriosis treatment. Undergraduate students will use cutting-edge techniques including methylation PCR arrays and Re-ChIP-qPCR. The first objective determines changes in methylation status of the CXCR4 promoter based on endometriotic lesion type and disease stage. The second objective investigates promoter bivalency, and the third examines the antagonizing role of KDM6 on CXCR4 epigenetic regulation. Performance occurs in Huntington, West Virginia. The award runs from September 1, 2026, through August 31, 2030. This is a Project Grant, a form of assistance funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $147.5k | 8/21/26 |