Project Grant R15HD121055
- The National Institutes of Health Office of the Director awarded University of California Irvine $6.132 million on August 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the neurobiological basis for cognitive dysfunction and dementia in aging adults with Down syndrome. The project uses spatial multi-omics techniques—combining transcriptomics, epigenomics, and proteomics—to analyze over 100 clinically characterized brain samples from individuals with Down...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Wisconsin System $568,615 on September 2, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the molecular mechanisms underlying synaptic deficiency in Down syndrome. The research project, titled "Molecular Mechanisms Underlying Synaptic Deficiency in Down Syndrome" (R01HD120347), will use isogenic trisomy 21 disorder-specific human...
- The National Institutes of Health Office of the Director awarded $2.693 million to the University of Wisconsin–Madison on September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) to establish an Alzheimer's disease biomarker clock in Down syndrome using positron emission tomography and plasma analytes. The research addresses the underrepresentation of individuals with Down syndrome in Alzheimer's disease therapeutic trials by characterizing biomarker progression in this...
- The National Institutes of Health Office of the Director awarded the University of New Mexico Health Sciences Center $419,375 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate mechanisms of vascular dysfunction in Down syndrome. The research examines endothelial dysfunction and glycocalyx depletion in a mouse model of Down syndrome (TCMAC21 mice) to understand cardiovascular disease risk in the Down syndrome population. The study investigates how...
- The National Institutes of Health Office of the Director awarded the Trustees of Boston University $763,348 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate how the HSA21-triplicated gene HMGN1 exacerbates neuropathological features in Down syndrome and Down syndrome-associated Alzheimer's disease. The research will examine HMGN1's dual mechanisms: its role as a nucleosome binding factor that facilitates chromatin accessibility and regulates genes...
- The National Institute on Aging at the Department of Health and Human Services awarded $429,262 to The Research Foundation For The State University of New York (Stony Brook University) on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R21AG093544). The award funds research into ciliopathy features in mouse models of Down syndrome. The project examines how trisomy 21 disrupts ciliary function in the brain's ventricular system, which is critical...
- The National Institute on Aging awarded The Washington University $406,707 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to conduct a national longitudinal study examining whether integrated dual-eligible special needs plans improve health outcomes for adults with intellectual disabilities and dementia who are dually enrolled in Medicare and Medicaid. The study addresses the absence of national research on dementia care access, quality, and outcomes among...
- The National Institutes of Health Office of the Director awarded the University of Kansas Medical Center Research Institute, Inc. $439,467 on August 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop and refine PUZZLEWALK 2.0, a gamified mobile health application designed to promote physical activity and cognitive training in adults with Down syndrome. The project will enhance the existing PUZZLEWALK app through user-centered design involving adults with Down...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- The National Institute on Aging, within the Department of Health and Human Services, awarded The Medical College of Wisconsin, Inc. $429,000 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how overexpression of human chromosome 21 (HSA21) orthologs affects neurodegeneration during aging in Caenorhabditis elegans. The project addresses variability in dementia onset among individuals with Down syndrome, which results from trisomy 21. While approximately 75...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded $980,965 to Montclair State University on August 13, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to conduct a project grant investigating spatial navigation as a domain-specific marker of cognitive decline in adults with Down syndrome. The research will recruit 40 adults with Down syndrome ages 35–50 to examine whether and how spatial navigation impairments relate to cognitive decline in this population. In Aim 1, the investigator will administer established navigation tasks (including the Hidden Goal Task) to determine whether spatial navigation performance distinguishes adults with Down syndrome exhibiting early Alzheimer's disease-like decline from those experiencing normative aging, and to identify which types of navigation tasks focusing on egocentric and allocentric reference frames and switching between them are most sensitive to cognitive decline. In Aim 2, the research will assess whether spatial navigation uniquely predicts cognitive decline beyond executive function and will correlate laboratory-based navigation scores with informant-reported everyday navigation behaviors to establish the ecological validity of laboratory findings in real-life contexts. Performance will take place in Montclair, New Jersey. The period of performance runs through July 31, 2029. This award is structured as a project grant, an assistance type subject to NIH peer review for scientific merit and program relevance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/1/26 | ||
| Not listed | $114.0k | 8/28/26 | ||
| Not listed | $433.5k | 8/17/26 |